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The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyo Jin | - |
dc.contributor.author | Kang, Eunjeong | - |
dc.contributor.author | Oh, Yun Kyu | - |
dc.contributor.author | Kim, Yeong Hoon | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.contributor.author | Yoo, Tae Hyun | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.contributor.author | Lee, Joongyub | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.date.accessioned | 2018-03-30T07:33:20Z | - |
dc.date.available | 2018-03-30T16:34:44Z | - |
dc.date.issued | 2018-03-05 | - |
dc.identifier.citation | BMC Nephrology, 19(1):51 | ko_KR |
dc.identifier.issn | 1471-2369 | - |
dc.identifier.uri | https://hdl.handle.net/10371/139657 | - |
dc.description.abstract | Background
Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort. Methods We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels. Left ventricular hypertrophy evaluated by left ventricular mass index (LVMI) and arterial stiffness measured by brachial-to-ankle pulse wave velocity (baPWV) were explored as cardiovascular parameters. Results Patients were 53.6 ± 12.2years old and 61.1% were male. The mean estimated glomerular filtration rate (eGFR) was 53.0 ± 30.7mL/min/1.73m2. The median serum klotho level was 536 (interquartile range [IQR]: 420–667) pg/mL. Advanced CKD stages were associated with lower serum klotho levels (P <0.001, P for linear trend < 0.001). Ascending quartiles of klotho were significantly associated with decreased LMVI (P <0.001, P for linear trend< 0.001). A multivariable linear regression model showed serum klotho had a significant inverse association with LVMI (β−0.04; 95% CI [confidence interval] -0.004, − 0.00007; P = 0.041). However, there was no significant association between serum klotho and baPWV after adjustment (β 0.003; 95% CI -0.04, 0.05; P = 0.876). Trial registration This trial was registered on ClinicalTrials.gov on 28 June 2012 (NCT01630486). Conclusions Serum klotho was an independent biomarker of LVMI, but not arterial stiffness. | ko_KR |
dc.description.sponsorship | This study was supported by the research program funded by the Korea Center for Disease Control and Prevention (2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, and 2016E3300200). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Serum klotho | ko_KR |
dc.subject | Soluble klotho | ko_KR |
dc.subject | Chronic kidney disease | ko_KR |
dc.subject | Left ventricular mass index | ko_KR |
dc.subject | Left ventricular hypertrophy | ko_KR |
dc.subject | Pulse wave velocity | ko_KR |
dc.title | The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김효진 | - |
dc.contributor.AlternativeAuthor | 강은정 | - |
dc.contributor.AlternativeAuthor | 오윤규 | - |
dc.contributor.AlternativeAuthor | 김영훈 | - |
dc.contributor.AlternativeAuthor | 한승혁 | - |
dc.contributor.AlternativeAuthor | 유태현 | - |
dc.contributor.AlternativeAuthor | 채동완 | - |
dc.contributor.AlternativeAuthor | 이중엽 | - |
dc.contributor.AlternativeAuthor | 안규리 | - |
dc.contributor.AlternativeAuthor | 오국환 | - |
dc.identifier.doi | 10.1186/s12882-018-0851-3 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-03-11T04:22:32Z | - |
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