S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Chemical and Biological Engineering (화학생물공학부) Journal Papers (저널논문_화학생물공학부)
Regulation of lubricin for functional cartilage tissue regeneration: a review
|dc.contributor.author||Hwang, Nathaniel S.||-|
|dc.identifier.citation||Biomaterials Research, 22(1):9||ko_KR|
Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and multifaceted matter is a major concern in the field of cartilage tissue engineering.
Although a noticeable progress has been made toward cartilage tissue regeneration through numerous approaches such as autologous chondrocyte implantation, osteochondral grafts, and microfracture technique, the functionality of engineered cartilage is a challenge for complete reconstruction of cartilage. Thus, delicate modulation of lubricin along with cell/scaffold application will expand the research on cartilage tissue engineering.
In this review, we will discuss the empirical analysis of lubricin from fundamental interpretation to the practical design of gene expression regulation.
|dc.description.sponsorship||This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016R1E1A1A01943393, NRF-2017M3A9C6029699).||ko_KR|
|dc.subject||Superficial zone protein||ko_KR|
|dc.title||Regulation of lubricin for functional cartilage tissue regeneration: a review||ko_KR|
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