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The effect of change in fasting glucose on the risk of myocardial infarction, stroke, and all-cause mortality: a nationwide cohort study

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dc.contributor.authorLee, Gyeongsil-
dc.contributor.authorKim, Sung Min-
dc.contributor.authorChoi, Seulggie-
dc.contributor.authorKim, Kyuwoong-
dc.contributor.authorJeong, Su-Min-
dc.contributor.authorSon, Joung Sik-
dc.contributor.authorYun, Jae-Moon-
dc.contributor.authorPark, Sang Min-
dc.date.accessioned2018-05-15T04:07:40Z-
dc.date.available2018-05-15T13:08:47Z-
dc.date.issued2018-04-07-
dc.identifier.citationCardiovascular Diabetology, 17(1):51ko_KR
dc.identifier.issn1475-2840-
dc.identifier.urihttps://hdl.handle.net/10371/139763-
dc.description.abstractBackground
The effect of change in blood glucose levels on the risk of cardiovascular disease among individuals without diabetes is currently unclear. We aimed to examine the association of change in fasting serum glucose with incident cardiovascular disease and all-cause mortality among representative large population.

Methods
We analyzed the data from retrospective cohort of Korean National Health Insurance Service. In total, 260,487 Korean adults aged over 40years, without diabetes mellitus and cardiovascular disease at baseline measured change in fasting serum glucose according to the criteria of impaired and diabetic fasting glucose status: normal fasting glucose (NFG, fasting glucose: < 100mg/dL), impaired fasting glucose (IFG, fasting glucose: 100.0–125.9mg/dL), and diabetic fasting glucose (DFG, fasting glucose: ≥ 126.0mg/dL). Compared to the persistently unchanged group (i.e. NFG to NFG or IFG to IFG), Cox proportional hazards regression analyses were performed in the changed group to obtain the hazards ratio (HR) with 95% confidence interval (CI) for the subsequent median 8-year myocardial infarction, stroke, and all-cause mortality.

Results
Compared to individuals with persistent NFG (i.e., NFG to NFG), individuals who shifted from NFG to DFG had an increased risk of stroke (HR [95% CI]: 1.19 [1.02–1.38]) and individuals who shifted from NFG to IFG or DFG had increased risks of all-cause mortality (HR [95% CI]: 1.08 [1.02–1.14] for NFG to IFG and 1.56 [1.39–1.75] for NFG to DFG). Compared to individuals with persistent IFG, individuals who shifted from IFG to DFG had an increased risk of MI and all-cause mortality (HR [95% CI]: 1.65 [1.20–2.27] and 1.16 [1.02–1.33], respectively).

Conclusions
Increasing fasting glucose in non-diabetic population is associated with risks of the MI, stroke, and all-cause mortality, which is more rapid, more severe.
ko_KR
dc.description.sponsorshipSung Min Kim and Kyuwoong Kim received a scholarship from the BK21-plus education program provided by the National Research Foundation of the Republic of Korea. This research was supported by Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Education (Grant No: 2017R1D1A1B03033721) in the Republic of Korea.ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectPrediabetesko_KR
dc.subjectBlood glucoseko_KR
dc.subjectMyocardial infarctionko_KR
dc.subjectStrokeko_KR
dc.subjectMortalityko_KR
dc.titleThe effect of change in fasting glucose on the risk of myocardial infarction, stroke, and all-cause mortality: a nationwide cohort studyko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이경실-
dc.contributor.AlternativeAuthor김성민-
dc.contributor.AlternativeAuthor최슬기-
dc.contributor.AlternativeAuthor김규웅-
dc.contributor.AlternativeAuthor정수민-
dc.contributor.AlternativeAuthor손정식-
dc.contributor.AlternativeAuthor윤재문-
dc.contributor.AlternativeAuthor박상민-
dc.identifier.doi10.1186/s12933-018-0694-z-
dc.rights.holderThe Author(s)-
dc.date.updated2018-04-08T03:29:13Z-
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