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Acquisition of pluripotency in the chick embryo occurs during intrauterine embryonic development via a unique transcriptional network

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dc.contributor.authorHan, Jae Yong-
dc.contributor.authorLee, Hyo Gun-
dc.contributor.authorPark, Young Hyun-
dc.contributor.authorHwang, Young Sun-
dc.contributor.authorKim, Sang Kyung-
dc.contributor.authorRengaraj, Deivendran-
dc.contributor.authorCho, Byung Wook-
dc.contributor.authorLim, Jeong Mook-
dc.date.accessioned2018-05-29T00:20:32Z-
dc.date.available2018-05-29T09:21:52Z-
dc.date.issued2018-04-10-
dc.identifier.citationJournal of Animal Science and Biotechnology, 9(1):31ko_KR
dc.identifier.issn2049-1891-
dc.identifier.urihttps://hdl.handle.net/10371/141237-
dc.description.abstractBackground
Acquisition of pluripotency by transcriptional regulatory factors is an initial developmental event that is required for regulation of cell fate and lineage specification during early embryonic development. The evolutionarily conserved core transcriptional factors regulating the pluripotency network in fishes, amphibians, and mammals have been elucidated. There are also species-specific maternally inherited transcriptional factors and their intricate transcriptional networks important in the acquisition of pluripotency. In avian species, however, the core transcriptional network that governs the acquisition of pluripotency during early embryonic development is not well understood.

Results
We found that chicken NANOG (cNANOG) was expressed in the stages between the pre-ovulatory follicle and oocyte and was continuously detected in Eyal-Giladi and Kochav stage I (EGK.I) to X. However, cPOUV was not expressed during folliculogenesis, but began to be detectable between EGK.V and VI. Unexpectedly, cSOX2 could not be detected during folliculogenesis and intrauterine embryonic development. Instead of cSOX2, cSOX3 was maternally inherited and continuously expressed during chicken intrauterine development. In addition, we found that the pluripotency-related genes such as cENS-1, cKIT, cLIN28A, cMYC, cPRDM14, and cSALL4 began to be dramatically upregulated between EGK.VI and VIII.

Conclusion
These results suggest that chickens have a unique pluripotent circuitry since maternally inherited cNANOG and cSOX3 may play an important role in the initial acquisition of pluripotency. Moreover, the acquisition of pluripotency in chicken embryos occurs at around EGK.VI to VIII.
ko_KR
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No.2015R1A3A2033826) and the International Research & Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning of Korea (NRF-2016K1A3A1A21005676).ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectAvianko_KR
dc.subjectEmbryonic developmentko_KR
dc.subjectNANOGko_KR
dc.subjectPluripotencyko_KR
dc.subjectTranscriptional factorko_KR
dc.titleAcquisition of pluripotency in the chick embryo occurs during intrauterine embryonic development via a unique transcriptional networkko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor한재용-
dc.contributor.AlternativeAuthor이효건-
dc.contributor.AlternativeAuthor박영현-
dc.contributor.AlternativeAuthor황영선-
dc.contributor.AlternativeAuthor김상경-
dc.contributor.AlternativeAuthor조병욱-
dc.contributor.AlternativeAuthor임정묵-
dc.identifier.doi10.1186/s40104-018-0246-0-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2018-04-15T03:24:31Z-
Appears in Collections:
College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Journal Papers (저널논문_농생명공학부)
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