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Increased Risk of Anxiety and Depression in Patients with Inflammatory Bowel Disease: A Nationwide Population-based Study in Korea : 염증성 장질환 환자에서의 불안증과 우울증의 위험도 분석: 전국민 기반 코호트 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김주성 | - |
dc.contributor.author | 최국환 | - |
dc.date.accessioned | 2018-05-29T04:54:48Z | - |
dc.date.available | 2018-05-29T04:54:48Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.other | 000000149771 | - |
dc.identifier.uri | https://hdl.handle.net/10371/142334 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의과대학 의학과, 2018. 2. 김주성. | - |
dc.description.abstract | Background/Aims: Inflammatory bowel disease (IBD) may be associated with psychological disorders. The aim of this study was to investigate the risk of anxiety and depression in patients with IBD.
Methods: We conducted a retrospective study using claim data from the National Healthcare Insurance service (NHIS) in Korea. The patients with Crohns disease (CD) and ulcerative colitis (UC) were identified through both ICD-10 codes and the rare/intractable disease registration program codes which provide co-payment reduction of up to 90% in Korea. We compared 15,569 IBD patients with 46,707 non-IBD controls matched by age and sex with a ratio of 1:3. Cases with newly diagnosed anxiety and depression were identified through ICD-10 codes in the study population, respectively. The Kaplan–Meier method was used to estimate the cumulative probability of anxiety and depression in IBD patients. Results: During the mean follow-up of 6 years, IBD patients experienced anxiety and depression more frequently than non-IBD controls, respectively (anxiety: 12.2% vs. 8.7%, p<0.001 | - |
dc.description.abstract | depression: 8.0% vs. 4.7%, p<0.001). In patients with CD, incidence rate (per 1,000 person-years) of anxiety was 19.51, compared to 13.26 in controls (hazard ratio [HR], 1.63 | - |
dc.description.abstract | 95% confidence interval [CI], 1.40-1.89 | - |
dc.description.abstract | p<0.001), and incidence rate of depression was 12.79, compared to 6.6 in controls (HR, 2.09 | - |
dc.description.abstract | 95% CI, 1.73-2.52 | - |
dc.description.abstract | p<0.001). In patients with UC, incidence rate (per 1,000 person-years) of anxiety was 28.9, compared to 19.87 in controls (HR, 1.60 | - |
dc.description.abstract | 95% CI, 1.44-1.77 | - |
dc.description.abstract | p<0.001), and incidence rate of depression was 16.49, compared to 9.23 per in controls (HR, 2.00 | - |
dc.description.abstract | 95% CI, 1.74-2.30 | - |
dc.description.abstract | p<0.001). The impact of CD on developing depression was more pronounced in male gender (adjusted HR, 1.58 | - |
dc.description.abstract | 95% CI, 1.41-1.76) than in female (adjusted HR, 1.21 | - |
dc.description.abstract | 95% CI, 1.00-1.47 | - |
dc.description.abstract | p=0.025 by interaction analysis).
Conclusion: The risk of anxiety and depression increased in the patients with IBD, respectively. Patients with IBD would be monitored carefully for the development of mood disorders. | - |
dc.description.tableofcontents | Introduction 1
Methods 3 Results 6 Discussion 16 References 19 Abstract (Korean) 22 | - |
dc.format | application/pdf | - |
dc.format.extent | 1069944 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Anxiety | - |
dc.subject | Crohn’s disease | - |
dc.subject | Depression | - |
dc.subject | Inflammatory bowel disease | - |
dc.subject | Ulcerative colitis | - |
dc.subject.ddc | 610 | - |
dc.title | Increased Risk of Anxiety and Depression in Patients with Inflammatory Bowel Disease: A Nationwide Population-based Study in Korea | - |
dc.title.alternative | 염증성 장질환 환자에서의 불안증과 우울증의 위험도 분석: 전국민 기반 코호트 연구 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Gukhwan Choi | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2018-02 | - |
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