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M1 macrophage recruitment correlates with worse outcome in SHH Medulloblastomas

DC Field Value Language
dc.contributor.authorLee, Chanhee-
dc.contributor.authorLee, Joongyub-
dc.contributor.authorChoi, Seung Ah-
dc.contributor.authorKim, Seung-Ki-
dc.contributor.authorWang, Kyu-Chang-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorKim, Se Hoon-
dc.contributor.authorLee, Ji Yeoun-
dc.contributor.authorPhi, Ji Hoon-
dc.date.accessioned2018-05-31T05:55:11Z-
dc.date.available2018-05-31T14:57:42Z-
dc.date.issued2018-05-08-
dc.identifier.citationBMC Cancer, 18(1):535ko_KR
dc.identifier.issn1471-2407-
dc.identifier.urihttps://hdl.handle.net/10371/142661-
dc.description.abstractBackground
Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functional role of their activated phenotype (M1/M2) remains controversial. Herein, we investigate the correlation between tumor-associated macrophage (TAM) recruitment within the MB subgroups and prognosis.

Methods
Molecular subgrouping was performed by a nanoString-based RNA assay on retrieved snap-frozen tissue samples. Immunohistochemistry (IHC) and immunofluorescence (IF) assays were performed on subgroup identified samples, and the number of polarized macrophages was quantified from IHC. Survival analyses were conducted on collected clinical data and quantified macrophage data.

Results
TAM (M1/M2) recruitment in SHH MB was significantly higher compared to that in other subgroups. A Kaplan-Meier survival curve and multivariate Cox regression demonstrated that high M1 expressers showed worse overall survival (OS) and progression-free survival (PFS) than low M1 expressers in SHH MB, with relative risk (RR) values of 11.918 and 6.022, respectively.

Conclusion
M1 rather than M2 correlates more strongly with worse outcome in SHH medulloblastoma.
ko_KR
dc.description.sponsorshipThe present study was financially supported by a grant from the National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea (1420020).ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectMedulloblastomako_KR
dc.subjectSonic hedgehogko_KR
dc.subjectMacrophageko_KR
dc.subjectRecruitmentko_KR
dc.subjectPrognosisko_KR
dc.titleM1 macrophage recruitment correlates with worse outcome in SHH Medulloblastomasko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이찬희-
dc.contributor.AlternativeAuthor이중엽-
dc.contributor.AlternativeAuthor최승아-
dc.contributor.AlternativeAuthor김승기-
dc.contributor.AlternativeAuthor왕규창-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor김세훈-
dc.contributor.AlternativeAuthor이지연-
dc.contributor.AlternativeAuthor피지훈-
dc.identifier.doi10.1186/s12885-018-4457-8-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2018-05-13T03:36:17Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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