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Risk factors for poor outcome in community-onset Clostridium difficile infection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eunyoung | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Bae, Ji Yun | - |
dc.contributor.author | Yoon, Doran | - |
dc.contributor.author | Hwang, Joo-Hee | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Bang, Ji Hwan | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Park, Sang Won | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.date.accessioned | 2018-07-27T06:11:59Z | - |
dc.date.available | 2018-07-27T15:12:41Z | - |
dc.date.issued | 2018-06-15 | - |
dc.identifier.citation | Antimicrobial Resistance & Infection Control, 7(1):75 | ko_KR |
dc.identifier.issn | 2047-2994 | - |
dc.identifier.uri | https://hdl.handle.net/10371/142760 | - |
dc.description.abstract | Background
A substantial portion of Clostridium difficile infection (CDI) cases occur in communities, and community-onset CDI (CO-CDI) can lead to serious complications including mortality. This study aimed to identify the risk factors for a poor outcome in CO-CDI. Methods We performed a retrospective review of all inpatients with CDI, in a 1300-bed tertiary-care hospital in Korea, from 2008 through 2015. CO-CDI was defined as CDI occurring within 48h of admission. Poor outcome was defined as follows: 1) all-cause 30-day mortality, 2) in-hospital mortality, or 3) surgery due to CDI. Results Of a total 1256 CDIs occurring over 8years, 152 (12.1%) cases were classified as CO-CDI and 23 (15.1%) had a poor outcome, including 22 (14.5%) cases of mortality and 2 (1.3%) cases of surgery. Patients with a poor outcome had a higher mean age than those without a poor outcome (75.8 vs. 69.6years, p = 0.03). The proportion of men and prior proton pump inhibitor (PPI) use were significantly higher in the poor outcome group (65.2% vs. 41.9%, p = 0.04; 39.1% vs. 17.6%, p = 0.02, respectively). Multivariate binary logistic model showed that PPI use and anemia (hemoglobin < 10g/dL) at presentation were significantly associated with a poor outcome (adjusted odds ratio [aOR], 3.76; 95% confidence interval [95CI], 1.26–11.21, aOR, 4.67; 95CI, 1.52–14.34, respectively). Conclusions Clinicians should not only be aware of the possibility of CDI in the community setting but also pay more attention to PPI-using elderly patients with anemia in consideration of a poor outcome. | ko_KR |
dc.description.sponsorship | This work was supported by the SNUBH Research Fund [Grant no. 02–2017-031]. The funding source had no role in the design of this study and did not influence the execution, analyses, interpretation of the data, or decision to submit results. | ko_KR |
dc.language.iso | en | ko_KR |
dc.subject | Clostridium difficile | ko_KR |
dc.subject | Community-acquired infections | ko_KR |
dc.subject | Anemia | ko_KR |
dc.subject | Proton pump inhibitors | ko_KR |
dc.subject | Mortality | ko_KR |
dc.subject | Risk factors | ko_KR |
dc.title | Risk factors for poor outcome in community-onset Clostridium difficile infection | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이은영 | - |
dc.contributor.AlternativeAuthor | 송경호 | - |
dc.contributor.AlternativeAuthor | 배지윤 | - |
dc.contributor.AlternativeAuthor | 윤도란 | - |
dc.contributor.AlternativeAuthor | 황주희 | - |
dc.contributor.AlternativeAuthor | 최평균 | - |
dc.contributor.AlternativeAuthor | 박완범 | - |
dc.contributor.AlternativeAuthor | 방지환 | - |
dc.contributor.AlternativeAuthor | 김의석 | - |
dc.contributor.AlternativeAuthor | 박상원 | - |
dc.contributor.AlternativeAuthor | 김남중 | - |
dc.contributor.AlternativeAuthor | 오명돈 | - |
dc.contributor.AlternativeAuthor | 김홍빈 | - |
dc.identifier.doi | 10.1186/s13756-018-0365-6 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-06-17T03:42:28Z | - |
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