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Associations of serum calcium levels and dietary calcium intake with incident type 2 diabetes over 10years: the Korean Genome and Epidemiology Study (KoGES)
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyoung-Nam | - |
dc.contributor.author | Oh, Se-Young | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.date.accessioned | 2018-10-05T00:33:52Z | - |
dc.date.available | 2018-10-05T09:36:43Z | - |
dc.date.issued | 2018-06-19 | - |
dc.identifier.citation | Diabetology & Metabolic Syndrome, 10(1):50 | ko_KR |
dc.identifier.issn | 1758-5996 | - |
dc.identifier.uri | https://hdl.handle.net/10371/142836 | - |
dc.description.abstract | Background
Previous evidence regarding the associations between serum calcium concentrations, dietary calcium intake, and type 2 diabetes (T2D) is limited. We investigated the longitudinal associations of serum calcium levels and dietary calcium intake with T2D development. Methods This study used data from the Ansung–Ansan cohort, a community-based, prospective cohort that was followed up for 10years. Cox regression models adjusted for potential confounders were used to evaluate the associations of serum calcium levels (mean, 9.41mg/dL) and dietary calcium intake (median, 389.59mg/day) with T2D incidence. Association between dietary calcium intake and serum calcium levels was assessed using linear regression models. Results Albumin-adjusted serum calcium levels were not associated with T2D risk (hazard ratio [HR] = 1.07, 95% confidence interval [CI] 0.96, 1.19, p-value = 0.2333). A one-unit increase in log-transformed, energy-adjusted dietary calcium intake was associated with a decreased risk of T2D (HR = 0.88, 95% CI 0.77, 1.00, p-value = 0.0460) and lower albumin-adjusted serum calcium levels (β = − 0.04, 95% CI − 0.07, − 0.02, p-value = 0.0014). The associations did not differ according to sex (all p-values for interaction > 0.10). Conclusions Serum calcium levels were not associated with T2D risk, while higher dietary calcium intake was associated with a decreased risk of T2D development. These results have public health implications for predicting and preventing T2D development, as well as providing guidelines for diet and calcium supplementation. | ko_KR |
dc.description.sponsorship | This study was supported by grants from the Korea Centers for Disease Con‑ trol, Republic of Korea (4845-301, 4851-302, and 4851-307). This study was also supported in part by the R&D Program for Society of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning, Republic of Korea (2014M3C8A5030619). The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Cohort study | ko_KR |
dc.subject | Dietary calcium | ko_KR |
dc.subject | Serum calcium | ko_KR |
dc.subject | Type 2 diabetes mellitus | ko_KR |
dc.title | Associations of serum calcium levels and dietary calcium intake with incident type 2 diabetes over 10years: the Korean Genome and Epidemiology Study (KoGES) | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김경남 | - |
dc.contributor.AlternativeAuthor | 오세영 | - |
dc.contributor.AlternativeAuthor | 홍윤철 | - |
dc.identifier.doi | 10.1186/s13098-018-0349-y | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2018-06-24T03:33:57Z | - |
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