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Prospective observations study protocol to investigate cost-effectiveness of various prenatal test strategies after the introduction of noninvasive prenatal testing
DC Field | Value | Language |
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dc.contributor.author | Kim, So Yeon | - |
dc.contributor.author | Lee, Seung Mi | - |
dc.contributor.author | Jun, Jong Kwan | - |
dc.contributor.author | Han, You Jung | - |
dc.contributor.author | Kim, Min Hyoung | - |
dc.contributor.author | Shim, Jae-Yoon | - |
dc.contributor.author | Lee, Mi-Young | - |
dc.contributor.author | Oh, Soo-young | - |
dc.contributor.author | Lee, JoonHo | - |
dc.contributor.author | Kim, Soo Hyun | - |
dc.contributor.author | Cha, Dong Hyun | - |
dc.contributor.author | Cho, Geum Joon | - |
dc.contributor.author | Kwon, Han-Sung | - |
dc.contributor.author | Kim, Byoung Jae | - |
dc.contributor.author | Park, Mi Hye | - |
dc.contributor.author | Cho, Hee Young | - |
dc.contributor.author | Ko, Hyun Sun | - |
dc.contributor.author | Ahn, Jeonghoon | - |
dc.contributor.author | Ryu, Hyun Mee | - |
dc.date.accessioned | 2018-11-13T07:55:03Z | - |
dc.date.available | 2018-11-13T16:56:41Z | - |
dc.date.issued | 2018-07-24 | - |
dc.identifier.citation | BMC Pregnancy and Childbirth, 18(1):307 | ko_KR |
dc.identifier.issn | 1471-2393 | - |
dc.identifier.uri | https://hdl.handle.net/10371/143520 | - |
dc.description.abstract | Background
Among the non-invasive screening methods for the identification of fetal aneuploidy, NIPT (non-invasive prenatal testing) shows the highest sensitivity and specificity in high-risk pregnancies. Due to the low false positive rate of NIPT, it is assumed that the implementation of NIPT as a primary screening method may reduce the number of invasive fetal tests and result in a similar or lowered cost in the overall detection of Down syndrome. However, most previous studies are based on theoretical economic analysis. This study aims to determine the cost effectiveness of various prenatal test strategies, including NIPT, in real clinical settings in both low risk and high risk pregnancies. Methods/design In this prospective observational study, women (< 24weeks) with singleton or twin pregnancies will be enrolled in 12 different healthcare institutions. The participants will be grouped based on the risks of fetal chromosomal abnormalities and will be counseled on the various screening or diagnostic methods, including NIPT, according to the aneuploidy risk. The final decision on screening or diagnostic methods will be made by patients after counseling. Questionnaires regarding factors affecting the decision on prenatal test will be answered by the participants and physicians. The economic analysis on final total costs will be compared according to the various prenatal test strategies. Discussion The results of present study are expected to have a significant impact on national policies in determining Korean prenatal screening test strategies and to help in developing novel and effective prenatal screening tests in the future. | ko_KR |
dc.description.sponsorship | This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HC15C1336). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Prenatal diagnosis | ko_KR |
dc.subject | NIPT | ko_KR |
dc.subject | Prenatal screening test, | ko_KR |
dc.subject | Prenatal genetic counseling | ko_KR |
dc.subject | Clinical practice guidelines | ko_KR |
dc.title | Prospective observations study protocol to investigate cost-effectiveness of various prenatal test strategies after the introduction of noninvasive prenatal testing | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김소연 | - |
dc.contributor.AlternativeAuthor | 이승미 | - |
dc.contributor.AlternativeAuthor | 전종관 | - |
dc.contributor.AlternativeAuthor | 한유정 | - |
dc.contributor.AlternativeAuthor | 김민형 | - |
dc.contributor.AlternativeAuthor | 심재윤 | - |
dc.contributor.AlternativeAuthor | 이미영 | - |
dc.contributor.AlternativeAuthor | 오수영 | - |
dc.contributor.AlternativeAuthor | 이준호 | - |
dc.contributor.AlternativeAuthor | 김수현 | - |
dc.contributor.AlternativeAuthor | 차동현 | - |
dc.contributor.AlternativeAuthor | 조금준 | - |
dc.contributor.AlternativeAuthor | 권한성 | - |
dc.contributor.AlternativeAuthor | 김병재 | - |
dc.contributor.AlternativeAuthor | 박미혜 | - |
dc.contributor.AlternativeAuthor | 조희영 | - |
dc.contributor.AlternativeAuthor | 고현선 | - |
dc.contributor.AlternativeAuthor | 안정훈 | - |
dc.contributor.AlternativeAuthor | 류현미 | - |
dc.identifier.doi | 10.1186/s12884-018-1930-y | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-07-29T03:38:44Z | - |
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