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The association between socioeconomic disparities and left ventricular hypertrophy in chronic kidney disease: results from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Kang, Eunjeong; Lee, Joongyub; Kim, Hyo Jin; Han, Miyeun; Kim, Woo Wan; Lee, Kyu-Beck; Sung, Suah; Yoo, Tae-Hyun; Chung, Wookyung; Ahn, Curie; Oh, Kook-Hwan
Issue Date
2018-08-16
Publisher
BioMed Central
Citation
BMC Nephrology, 19(1):203
Keywords
Chronic kidney diseaseLeft ventricular hypertrophyEducationIncomeSocioeconomic status
Abstract
Background
Left ventricular hypertrophy (LVH) is one of the risk factors for cardiovascular (CV) disease and mortality. However, the relationship between socioeconomic status (SES) and LVH in chronic kidney disease remains unclear.

Methods
Data were collected from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD, NCT01630486 at
http://www.clinicaltrials.gov

). Subjects with CKD and aged ≥50 were included. SES was characterized based on monthly income and educational attainment, each of which was divided into three strata. LVH was defined as LV mass/height2.7 ≥ 47 g/m2.7 in female and ≥ 50 g/m2.7 in male. Age, sex, diabetes, CKD stage, body mass index, blood pressure and physical activity were included as covariates.

Results
A total of 1361 patients were included. Mean age was 60.9 ± 6.9 years, and 63.2% were men. Higher education level was associated with higher monthly income (P for trend < 0.001). The lowest education level was independently associated with LVH (lower than high school, adjusted odds ratio [OR] 1.485, 95% CI 1.069–2.063, P = 0.018; completed high school, adjusted OR 1.150, 95% confidence interval [CI] 0.834–1.584, P = 0.394; highest education level as the reference). Monthly income level was marginally associated with LVH after adjusting for covariates ($1500-4500, adjusted OR 1.230, 95% CI 0.866–1.748, P = 0.247; < $1500, adjusted OR 1.471, 95% CI 1.002–2.158, P = 0.049; > $4500; reference).

Conclusions
In the CKD population, lower SES, defined by educational attainment and low income level exhibited a significant association with LVH, respectively. Longitudinal follow-up will reveal whether lower SES is associated with poor CKD outcomes.
ISSN
1471-2369
Language
English
URI
https://hdl.handle.net/10371/143533
DOI
https://doi.org/10.1186/s12882-018-1005-3
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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