Publications
Detailed Information
Predictors for false-negative QuantiFERON-TB Gold assay results in patients with extrapulmonary tuberculosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Youn Jeong | - |
dc.contributor.author | Kang, Ji Young | - |
dc.contributor.author | Kim, Sang Il | - |
dc.contributor.author | Chang, Mee Soo | - |
dc.contributor.author | Kim, Yang Rae | - |
dc.contributor.author | Park, Yeon Joon | - |
dc.date.accessioned | 2018-11-27T06:37:20Z | - |
dc.date.available | 2018-11-27T15:39:16Z | - |
dc.date.issued | 2018-09-10 | - |
dc.identifier.citation | BMC Infectious Diseases, 18(1):457 | ko_KR |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/143555 | - |
dc.description.abstract | Backgrounds
Extrapulmonary tuberculosis (EPTB) is a heterogeneous disease, and diagnosis is sometimes difficult. We investigated the diagnostic performance of the QuantiFERON-TB Gold assay (QFT-GIT) according to sites of EPTB and predictors for false-negative QFT-GIT results. Methods A total of 2176 patients were registered with active TB from January 2012 to December 2016 in Seoul St. Marys Hospital, a 1200-bed tertiary teaching hospital in Seoul, Korea. We retrospectively reviewed the medical records of 163 EPTB patients who underwent QFT-GIT. Results False negative QFT-GIT results were found in 28.8% (95% CI 0.22–0.36) of patients with EPTB. In the proven TB group, negative QFT-GIT results were found in 28.6% (95% CI 0.04–0.71) of pleural, 8.3% 0.002–0.38of lymph node, 8.3% (95% CI 0.002–0.38) of skeletal and 5.8% (95% CI 0.001–0.28) of gastrointestinal TB cases. Among probable TB cases, QFT-GIT negative results were identified in 46.2% (95% CI 0.19–0.75) of skeletal, 33.3% (95% CI 10–0.65) of pericardial, 30.8% (95% CI 0.09–0.61) of pleural and 17.2% (95% CI 0.10–0.56) of gastrointestinal TB cases. In the possible TB cases, central nervous system TB (n = 21) was most frequent, and 66.7% (95% CI 0.43–0.85) of those showed QFT-GIT negative results. By multivariate analysis, possible TB was independently associated with false-negative QFT-GIT results (OR 4.92, 95% CI 1.51–16.06, p = 0.008). Conclusions Prudent interpretation of QFT-GIT results might be needed according to anatomic site of involvement and diagnostic criteria in patients with high suspicion of EPTB. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | IFN-gamma release assay | ko_KR |
dc.subject | Extrapulmonary tuberculosis | ko_KR |
dc.subject | False negative | ko_KR |
dc.title | Predictors for false-negative QuantiFERON-TB Gold assay results in patients with extrapulmonary tuberculosis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김윤정 | - |
dc.contributor.AlternativeAuthor | 강지영 | - |
dc.contributor.AlternativeAuthor | 김상일 | - |
dc.contributor.AlternativeAuthor | 장미수 | - |
dc.contributor.AlternativeAuthor | 김양래 | - |
dc.contributor.AlternativeAuthor | 박연준 | - |
dc.identifier.doi | 10.1186/s12879-018-3344-x | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-09-16T03:19:35Z | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.