Browse

Effect of dose rate on pulmonary toxicity in patients with hematolymphoid malignancies undergoing total body irradiation

Cited 10 time in Web of Science Cited 9 time in Scopus
Authors
Kim, Dong-Yun; Kim, Il Han; Yoon, Sung-Soo; Kang, Hyoung Jin; Shin, Hee Young; Kang, Hyun-Cheol
Issue Date
2018-09-18
Publisher
BioMed Central
Citation
Radiation Oncology, 13(1):180
Keywords
Hematolymphoid malignancyTotal body irradiationPulmonary toxicityDose rate
Abstract
Background
This study evaluated the effect of radiation dose rate in patients with hematolymphoid malignancies undergoing myeloablative conditioning with total body irradiation (TBI), for hematopoietic stem cell transplantation.

Methods
The incidence of pulmonary toxicity (PT) and treatment efficacy were compared between the conventional (≥ 6 cGy/min) and reduced dose rate (< 6 cGy/min). Seventy-seven patients receiving once-daily TBI between 2000 and 2016 were reviewed. We compared the cumulative rate of PT, overall survival (OS), relapse, and transplantation-related mortality (TRM) between conventional (n = 54) and reduced (n = 23) groups. Factors associated with PT were assessed in the presence of competing risks.

Results
The median follow-up time was 40.7 months, and PT occurred in 50 patients (64.9%). On multivariate analyses, the groups classified by the dose rate (P = 0.010), total dose (P = 0.025), and conditioning regimen (P = 0.029) were significant factors for the development of PT. OS was significantly reduced when PT occurred (P < 0.001). However, the OS, relapse, and TRM were not different between the two groups.

Conclusions
In summary, about two-thirds of the patients undergoing daily TBI experienced PT, which affected OS. Therefore, reducing the dose rate (less than 6 cGy/min) of TBI can decrease the risk of PT, without compromising the treatment efficacy.
ISSN
1748-717X
Language
English
URI
https://hdl.handle.net/10371/144949
DOI
https://doi.org/10.1186/s13014-018-1116-9
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Radiation Oncology (방사선종양학전공)Journal Papers (저널논문_방사선종양학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse