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Cyclooxygenase-2 and inducible nitric oxide synthase expression in thyroid neoplasms and their clinicopathological correlation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyung-Hee | - |
dc.contributor.author | Kim, Seong-Ho | - |
dc.contributor.author | Kim, Seok Hyung | - |
dc.contributor.author | Back, Jong-Ho | - |
dc.contributor.author | Park, Mee-Ja | - |
dc.contributor.author | Kim, Jin-Man | - |
dc.date.accessioned | 2009-11-24T22:46:54Z | - |
dc.date.available | 2009-11-24T22:46:54Z | - |
dc.date.issued | 2006-12-21 | - |
dc.identifier.citation | J Korean Med Sci. 2006 Dec;21(6):1064-9. | en |
dc.identifier.issn | 1011-8934 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17179688 | - |
dc.identifier.uri | https://hdl.handle.net/10371/14627 | - |
dc.description.abstract | To evaluate the expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in thyroid neoplasms in a Korean population, we studied a total of 154 cases: papillary carcinoma of classical type (PTC), 86; follicular adenoma (FA), 21; follicular carcinoma (FC), 35; medullary carcinoma (MC), 3; undifferentiated carcinoma (UC), 5; and Hurthle cell neoplasm (HN), 4. Using immunohistochemical staining, COX-2 expression was detected in 62 (72.1%) PTC specimens, 5 (23.8%) FA specimens, 10 (28.6%) FC specimens, 0 (0.0%) MC specimens, 1 (20.0%) UC specimen, and 3 (75%) HN specimens. iNOS expression was detected in 66 (76.7%) PTC specimens, 4 (19.0%) FA specimens, 13 (37.1%) FC specimens, 0 (0.0%) MC specimens, 3 (60.0%) UC specimens, and 4 (100%) HN specimens. The results showed that COX-2 and iNOS were frequently expressed in the PTC and HN specimens, and iNOS was more frequently overexpressed in the FC specimens than in the FA specimens. In PTC, COX-2 and iNOS were significantly overexpressed in patients over 45 yr of age (p=0.029, p=0.041), and iNOS expression was increased in patients with a large primary tumor (p=0.028). These results suggest that the upregulation of COX-2 and iNOS may contribute to the tumor progression of thyroid gland, particularly in PTC and HN, and iNOS may play an adjuvant role during the tumor progression of FC. | en |
dc.language.iso | en | en |
dc.publisher | Korean Academy of Medical Science | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Cyclooxygenase 2/*analysis | en |
dc.subject | Female | en |
dc.subject | Gene Expression Profiling | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Proteins/*analysis | en |
dc.subject | Nitric Oxide Synthase Type II/*analysis | en |
dc.subject | Reproducibility of Results | en |
dc.subject | Sensitivity and Specificity | en |
dc.subject | Statistics as Topic | en |
dc.subject | Thyroid Neoplasms/*diagnosis/*enzymology | en |
dc.subject | Tissue Distribution | en |
dc.subject | Tumor Markers, Biological/*analysis | en |
dc.title | Cyclooxygenase-2 and inducible nitric oxide synthase expression in thyroid neoplasms and their clinicopathological correlation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김경희 | - |
dc.contributor.AlternativeAuthor | 김성호 | - |
dc.contributor.AlternativeAuthor | 김석형 | - |
dc.contributor.AlternativeAuthor | 백종호 | - |
dc.contributor.AlternativeAuthor | 박미자 | - |
dc.contributor.AlternativeAuthor | 김진만 | - |
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