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The association of tumor necrosis factor superfamily 13 with recurrence of immunoglobulin A nephropathy in living related kidney transplantation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, Hyung Ah | - |
dc.contributor.author | Han, Seung Seok | - |
dc.contributor.author | Lee, Sunhwa | - |
dc.contributor.author | Kim, Joo Young | - |
dc.contributor.author | Yang, Seung Hee | - |
dc.contributor.author | Lee, Hajeong | - |
dc.contributor.author | Yang, Jae Seok | - |
dc.contributor.author | Lee, Jung Pyo | - |
dc.contributor.author | Joo, Kwon Wook | - |
dc.contributor.author | Lim, Chun Soo | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Han, Jin Suk | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.date.accessioned | 2019-03-18T04:40:54Z | - |
dc.date.available | 2019-03-18T13:42:44Z | - |
dc.date.issued | 2019-01-31 | - |
dc.identifier.citation | BMC Nephrology. 2019 Jan 31;20(1):33 | ko_KR |
dc.identifier.issn | 1471-2369 | - |
dc.identifier.uri | https://hdl.handle.net/10371/147146 | - |
dc.description.abstract | Background
An increasing amount of evidence has demonstrated an association between an increase in the level of tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) progression. We aimed to evaluate if the level of pre-transplant serum TNFSF13 is predictive of IgAN recurrence after kidney transplantation. Methods This analysis was based on the clinical and laboratory data of 69 patients with IgAN who underwent first kidney transplantation with no evidence of mesangial IgA deposits in zero-time transplantation biopsy. We measured pre-transplant serum TNFSF13, total IgA, and galactose-deficient IgA1 levels. Results The recurrence rate of IgAN over a median follow-up duration of 5.1 years was 15.9% (11/69 patients), with a mean time to the first recurrence of 1.7 years. The high pre-transplant TNFSF13 level was associated with IgAN recurrence after kidney transplantation among patients who received a graft from a living related donor. Conclusions This study highlights association of TNFSF13 levels in recurrent IgAN patients who undergo living related donor transplantation. Further research is needed to clarify mechanisms by which TNFSF13 affects the recurrence of IgA nephropathy. | ko_KR |
dc.description.sponsorship | This study was supported by a grant from the Seoul National University Hospital Research Fund (3020130050). The funder had no role in study design, data collection and analysis, and interpretation of data and in writing the manuscript. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | IgA nephropathy | ko_KR |
dc.subject | Tumor necrosis factor superfamily 13 | ko_KR |
dc.subject | Recurrence | ko_KR |
dc.title | The association of tumor necrosis factor superfamily 13 with recurrence of immunoglobulin A nephropathy in living related kidney transplantation | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12882-019-1222-4 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2019-02-03T04:18:43Z | - |
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