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Risk of acute exacerbations in chronic obstructive pulmonary disease associated with biomass smoke compared with tobacco smoke

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dc.contributor.authorCho, Jaeyoung-
dc.contributor.authorLee, Chang-Hoon-
dc.contributor.authorHwang, Seung-sik-
dc.contributor.authorKim, Ki Uk-
dc.contributor.authorLee, Sang Haak-
dc.contributor.authorPark, Hye Yun-
dc.contributor.authorPark, Seoung Ju-
dc.contributor.authorMin, Kyung Hoon-
dc.contributor.authorOh, Yeon-Mok-
dc.contributor.authorYoo, Kwang Ha-
dc.contributor.authorJung, Ki-Suck-
dc.date.accessioned2019-03-25T04:38:28Z-
dc.date.available2019-03-25T13:39:38Z-
dc.date.issued2019-03-22-
dc.identifier.citationBMC Pulmonary Medicine. 2019 Mar 22;19(1):68ko_KR
dc.identifier.issn1471-2466-
dc.identifier.urihttp://hdl.handle.net/10371/147212-
dc.description.abstractBackground
Risk of exacerbations in chronic obstructive pulmonary disease (COPD) associated with biomass smoke has not been well addressed, although biomass smoke is similar in composition to tobacco smoke.

Methods
To investigate whether the risk of exacerbations in COPD associated with biomass smoke differs from that in COPD associated with tobacco smoke, we recruited patients with COPD from two Korean multicenter prospective cohorts. In a multiple linear regression model, the standardized regression coefficient (β) of biomass smoke exposure ≥25 years was most similar to that (β′) of tobacco smoke exposure ≥10 pack-years (β = − 0.13 and β′ = − 0.14). We grouped patients with COPD into four categories based on the above cut-offs: Less Tobacco-Less Biomass, Less Tobacco-More Biomass, More Tobacco-Less Biomass, and More Tobacco-More Biomass. The main outcome was the incidence of moderate or severe exacerbations.

Results
Among 1033 patients with COPD, 107 were included in Less Tobacco-Less Biomass (mean age: 67 years, men: 67%), 40 in Less Tobacco-More Biomass (mean age: 70 years, men: 35%), 631 in More Tobacco-Less Biomass (mean age: 68 years, men: 98%), and 255 in More Tobacco-More Biomass (mean age: 69 years, men: 97%). The incidence rates of exacerbations were not significantly different between Less Tobacco-More Biomass and More Tobacco-Less Biomass (adjusted incidence rate ratio, 1.03; 95% confidence interval, 0.56–1.89; P = 0.921). No interaction between sex and tobacco and biomass smoke was observed. When propensity score matching with available covariates including age and sex was applied, a similar result was observed.

Conclusions
Patients with COPD associated with biomass smoke and those with COPD associated with tobacco smoke had a similar risk of exacerbations. This suggests that patients with COPD associated with biomass smoke should be treated actively.
ko_KR
dc.description.sponsorshipNone declared.ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectChronic obstructive pulmonary diseaseko_KR
dc.subjectBiomass smokeko_KR
dc.subjectTobacco smokeko_KR
dc.subjectExacerbationko_KR
dc.titleRisk of acute exacerbations in chronic obstructive pulmonary disease associated with biomass smoke compared with tobacco smokeko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor조재영-
dc.contributor.AlternativeAuthor이창훈-
dc.contributor.AlternativeAuthor황승식-
dc.contributor.AlternativeAuthor김기욱-
dc.contributor.AlternativeAuthor이상학-
dc.contributor.AlternativeAuthor박혜윤-
dc.contributor.AlternativeAuthor박성주-
dc.contributor.AlternativeAuthor민경훈-
dc.contributor.AlternativeAuthor오연목-
dc.contributor.AlternativeAuthor유광하-
dc.contributor.AlternativeAuthor정기석-
dc.identifier.doi10.1186/s12890-019-0833-7-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2019-03-24T04:20:32Z-
Appears in Collections:
Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Journal Papers (저널논문_보건학과)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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