Gene expression profile of anti-inflammatory action of rutaecarpine with microarray module on in-vitro inflammatory model of porcine chondrogenic satellite cells isolated from femoro-petallar chondular regions of piglets

Abstract

Rutaecarpine have been studied in the past particularly for inflammatory reactions to overcome side effects of conventionally used chemicals for the purpose. However, the molecular mechanisms of rutaecarpine have not so far been addressed particularly on osteoarthritis. Therefore, we carried out gene expression profiling in an effort to understand the effect of rutaecarpine on porcine chondrocytes using microarray. The present study provides novel insights into the gene mechanisms possibly involved in cellular metabolism, apoptosis leading to antiinflammation.