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Genetic polymorphisms of eNOS, hormone receptor status, and survival of breast cancer

Cited 32 time in Web of Science Cited 32 time in Scopus
Authors
Choi, Ji-Yeob; Lee, Kyoung-Mu; Noh, Dong-Young; Ahn, Sei-Hyun; Lee, Jong-Eun; Han, Wonshik; Jang, In-Jin; Shin, Sang-Goo; Yoo, Keun-Young; Hayes, Richard B; Kang, Daehee
Issue Date
2006-07-06
Publisher
Springer Verlag
Citation
Breast Cancer Res Treat. 2006 Nov;100(2):213-8. Epub 2006 Jul 4
Keywords
AdultAgedAged, 80 and overBreast Neoplasms/chemistry/*genetics/mortalityFemaleHumansMiddle AgedNitric Oxide Synthase Type III/*genetics*Polymorphism, GeneticReceptors, Estrogen/*analysisReceptors, Progesterone/*analysis
Abstract
The endothelial cell-specific form of nitric oxide synthase (eNOS) may play an important role in tumor progression via angiogenesis or apoptosis. We studied eNOS -786T > C and 894G > T (Glu298Asp), two functionally significant SNPs, in relation to hazard of breast cancer recurrence or death in 873 women with incident, non-metastatic breast cancer, recruited from two teaching hospitals in Seoul, Korea, 1995-2002. Hazards were estimated by Cox proportional hazard models, in relation to genotype, adjusting for hormone receptor status, lymph node involvement, and tumor size. Women carriers of the eNOS -786C allele had significantly increased hazards of breast cancer recurrence or death, compared with women having the TT genotype (HR = 2.1, 95% CI = 1.03-4.33); risks increased up to 3-fold in ER positive cases (HR = 3.2, 95% CI = 0.95-10.50). The hazard was also increased in eNOS 894T carriers, however, it did not reach statistical significance (HR = 1.8, 95% CI = 0.85-3.93). The combined genotypes containing -786C or 894T was associated with a 2.5-fold risk, compared to the TT-GG genotypes, the most dominant genotype combination (95% CI = 1.29-4.68), with the greatest risks in ER positive cases (HR = 4.9, 95% CI = 1.31-18.36). These results indicate that the eNOS -786C polymorphism, and possibly the 894T polymorphism, are associated with breast cancer recurrence and death, particularly in women with ER positive tumors.
ISSN
0167-6806 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16821086

http://hdl.handle.net/10371/15273
DOI
https://doi.org/10.1007/s10549-006-9245-5
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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