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Genetic polymorphisms of eNOS, hormone receptor status, and survival of breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Ji-Yeob | - |
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Ahn, Sei-Hyun | - |
dc.contributor.author | Lee, Jong-Eun | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Jang, In-Jin | - |
dc.contributor.author | Shin, Sang-Goo | - |
dc.contributor.author | Yoo, Keun-Young | - |
dc.contributor.author | Hayes, Richard B | - |
dc.contributor.author | Kang, Daehee | - |
dc.date.accessioned | 2009-11-25T05:11:43Z | - |
dc.date.available | 2009-11-25T05:11:43Z | - |
dc.date.issued | 2006-07-06 | - |
dc.identifier.citation | Breast Cancer Res Treat. 2006 Nov;100(2):213-8. Epub 2006 Jul 4 | en |
dc.identifier.issn | 0167-6806 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16821086 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15273 | - |
dc.description.abstract | The endothelial cell-specific form of nitric oxide synthase (eNOS) may play an important role in tumor progression via angiogenesis or apoptosis. We studied eNOS -786T > C and 894G > T (Glu298Asp), two functionally significant SNPs, in relation to hazard of breast cancer recurrence or death in 873 women with incident, non-metastatic breast cancer, recruited from two teaching hospitals in Seoul, Korea, 1995-2002. Hazards were estimated by Cox proportional hazard models, in relation to genotype, adjusting for hormone receptor status, lymph node involvement, and tumor size. Women carriers of the eNOS -786C allele had significantly increased hazards of breast cancer recurrence or death, compared with women having the TT genotype (HR = 2.1, 95% CI = 1.03-4.33); risks increased up to 3-fold in ER positive cases (HR = 3.2, 95% CI = 0.95-10.50). The hazard was also increased in eNOS 894T carriers, however, it did not reach statistical significance (HR = 1.8, 95% CI = 0.85-3.93). The combined genotypes containing -786C or 894T was associated with a 2.5-fold risk, compared to the TT-GG genotypes, the most dominant genotype combination (95% CI = 1.29-4.68), with the greatest risks in ER positive cases (HR = 4.9, 95% CI = 1.31-18.36). These results indicate that the eNOS -786C polymorphism, and possibly the 894T polymorphism, are associated with breast cancer recurrence and death, particularly in women with ER positive tumors. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Breast Neoplasms/chemistry/*genetics/mortality | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Middle Aged | en |
dc.subject | Nitric Oxide Synthase Type III/*genetics | en |
dc.subject | Receptors, Estrogen/*analysis | en |
dc.subject | Receptors, Progesterone/*analysis | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | Genetic polymorphisms of eNOS, hormone receptor status, and survival of breast cancer | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최지엽 | - |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.contributor.AlternativeAuthor | 안세현 | - |
dc.contributor.AlternativeAuthor | 이종은 | - |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 장인진 | - |
dc.contributor.AlternativeAuthor | 신상구 | - |
dc.contributor.AlternativeAuthor | 유근영 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.identifier.doi | 10.1007/s10549-006-9245-5 | - |
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