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Differential sensitivity of three forms of hippocampal synaptic potentiation to depotentiation

Cited 3 time in Web of Science Cited 3 time in Scopus
Authors
Park, Pojeong; Sanderson, Thomas M; Bortolotto, Zuner A; Georgiou, John; Zhuo, Min; Kaang, Bong-Kiun; Collingridge, Graham L
Issue Date
2019-04-03
Citation
Molecular Brain, 12(1):30
Keywords
: Long-term potentiationDepotentiationHippocampus
Abstract
Theta-burst stimulation (TBS) induces short-term potentiation (STP) plus two types of transcriptionally-independent forms of long-term potentiation (LTP), termed LTP1 and LTP2. We have compared the susceptibility of these three types of synaptic plasticity to depotentiation, induced by low frequency stimulation (LFS; 2 Hz for 10 min) at the Schaffer collateral-commissural pathway in area CA1 of adult rat hippocampal slices. In interleaved experiments, STP and LTP were induced by three episodes of either compressed or spaced TBS (cTBS or sTBS). LFS had a more pronounced effect on the LTP induced by the cTBS. One traditional interpretation of these results is a difference in the time-dependent immunity against depotentiation. We suggest an alternative explanation: LFS rapidly reverses STP to reveal a slowly developing LTP. The cTBS protocol induces LTP1 that is moderately sensitive to depotentiation. The sTBS induces an additional component of LTP (LTP2) that is resistant to depotentiation.
ISSN
1756-6606
Language
English
URI
https://hdl.handle.net/10371/153143
DOI
https://doi.org/10.1186/s13041-019-0451-6
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College of Natural Sciences (자연과학대학)Brain and Cognitive Sciences (뇌인지과학과)Journal Papers (저널논문_뇌인지과학과)
College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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