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Reactive Oxygen Species Downregulate Catalase Expression via Methylation of a CpG Island in the Oct-1 Promoter
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 정구흥 | - |
dc.contributor.author | 전소연 | - |
dc.date.accessioned | 2019-06-25T15:53:36Z | - |
dc.date.available | 2019-06-25T15:53:36Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.other | 000000001296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/155042 | - |
dc.identifier.uri | http://dcollection.snu.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000001296 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 생명과학부, 2012. 2. 정구흥. | - |
dc.description.abstract | Reactive oxygen species (ROS) caused oxidative stress plays a key role in carcinogenesis. The POU domain transcription factor Oct-1 and catalase is closely associated with ROS. However, a correlation between these two key proteins has not been demonstrated before. In this report, we show that Oct-1 acts as an activator of catalase, by binding to the catalase promoter in hepatocellular carcinoma (HCC) cell lines. In addition, we suggest that Oct-1 is downregulated by ROS via CpG island methylation in its promoter. These findings contribute to a better understanding of the epigenetic changes induced by ROS in the process of carcinogenesis. | - |
dc.format.extent | 30 | - |
dc.language.iso | eng | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 570 | - |
dc.title | Reactive Oxygen Species Downregulate Catalase Expression via Methylation of a CpG Island in the Oct-1 Promoter | - |
dc.type | Thesis | - |
dc.type | Dissertation | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 생명과학부 | - |
dc.date.awarded | 2012-02 | - |
dc.contributor.major | 분자유전학 | - |
dc.identifier.holdings | 000000000006▲000000000011▲000000001296▲ | - |
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