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Synthesis and characterization of chitosan-conjugated arachidic acid for self-assembled nanoparticles as a new drug delivery carrier
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Dae-Duk | - |
dc.contributor.author | 김연화 | - |
dc.date.accessioned | 2019-06-25T16:04:57Z | - |
dc.date.available | 2019-06-25T16:04:57Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.other | 000000000354 | - |
dc.identifier.uri | https://hdl.handle.net/10371/155192 | - |
dc.identifier.uri | http://dcollection.snu.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000000354 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2012. 2. Kim, Dae-Duk. | - |
dc.description.abstract | Chitosan oligosaccharide (CSO), a water–soluble low molecular weight chitosan, was hydrophobically modified with arachidic acid (AA), long chain fatty acid, through an EDC coupling reaction with different ratio of AA/CSO. Conjugation of synthesized chitosan oligosaccharide-conjugated arachidic acid (CSO-AA) was confirmed by FT-IR and 1H-NMR. The substitution ratios increased from 0.4 to 2.33 molar of AA substitution on CSO when the initial AA/CSO ratios increased during synthesis. Formation and characteristic of self-assembled nanoparticles of CSO-AA were determined by fluorescence spectroscopy, dynamic light scattering method and transmission electron microscopy. The critical micelle concentration (CMC) values decreased from 1.87 to 1.02 µg/ml with increasing the substitution ratio. The CSO-AAs formed spherical shape self-assembled nanoparticles with the particle sizes in the range of 65-77 nm depending on the substitution ratio. The zeta potentials were in the range of 2.74-16.15 mV. The results showed CSO-AA was successfully synthesized which could be applied for the preparation of self-assembled nanoparticles for hydrophobic drugs. | - |
dc.format.extent | 35 | - |
dc.language.iso | eng | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 615 | - |
dc.title | Synthesis and characterization of chitosan-conjugated arachidic acid for self-assembled nanoparticles as a new drug delivery carrier | - |
dc.type | Thesis | - |
dc.type | Dissertation | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 약학과 | - |
dc.date.awarded | 2012-02 | - |
dc.identifier.holdings | 000000000006▲000000000011▲000000000354▲ | - |
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