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Effects of red ginseng extracts on HIF-1α-mediated cellular responses to hypoxia
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 박종완 | - |
dc.contributor.author | 최용준 | - |
dc.date.accessioned | 2019-06-25T16:14:15Z | - |
dc.date.available | 2019-06-25T16:14:15Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.other | 000000002013 | - |
dc.identifier.uri | https://hdl.handle.net/10371/155308 | - |
dc.identifier.uri | http://dcollection.snu.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000002013 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의과학과, 2012. 2. 박종완. | - |
dc.description.abstract | Water extract of Korean red ginseng (KRGW) contains numerous bioactive ginsenosides and is very popularly used as a multi-purpose medicine for health improvement. KRGW has been in the limelight because of its clinical benefit in cancer control. A growing body of evidence suggests that HIF-1 plays critical roles in tumor promotion under hypoxia and that it is a most compelling target for cancer therapy. We here addressed the effect of KRGW on HIF-1-mediated adaptation to hypoxia. In both Hep3B cancer and HEK293 immortalized normal cell lines, KRGW attenuated the expression of hypoxia-induced genes without apparent cytotoxicity. Mechanistically, KRGW did not affect the synthesis, degradation, and translocation of HIF-1α in hypoxia. Interestingly, KRGW was identified to repress the transcriptional activity of HIF-1α by interfering with the dimerization between HIF-1α and HIF-1β(ARNT). To identify HIF-inhibiting ingredient(s), we examined the effects of major ginsenosides on HIF-1 activity, but all ginsenosides tested failed to inactivate HIF-1. Based on these results, we propose that the HIF-1 inhibition underlies the anticancer effect of ginseng. It is also implied that KRGW could be an anticancer medicine to target hypoxic tumors. | - |
dc.format.extent | 34 | - |
dc.language.iso | eng | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 610.72 | - |
dc.title | Effects of red ginseng extracts on HIF-1α-mediated cellular responses to hypoxia | - |
dc.type | Thesis | - |
dc.type | Dissertation | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 의과학과 | - |
dc.date.awarded | 2012-02 | - |
dc.contributor.major | 약리학 | - |
dc.identifier.holdings | 000000000006▲000000000011▲000000002013▲ | - |
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