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Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement

Cited 25 time in Web of Science Cited 28 time in Scopus
Authors
Lee, Kyoung-Mu; Choi, Ji-Yeob; Lee, Jong Eun; Noh, Dong-Young; Ahn, Sei-Hyun; Han, Wonshik; Yoo, Keun-Young; Hayes, Richard B; Kang, Daehee
Issue Date
2007-01-31
Publisher
Springer Verlag
Citation
Breast Cancer Res Treat. 2007 Dec;106(3):433-8. Epub 2007 Jan 30
Keywords
AdultAgedBreast Neoplasms/*genetics/pathologyCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansLymphatic MetastasisMiddle AgedNitric Oxide Synthase Type III/*genetics*Polymorphism, GeneticRisk
Abstract
Endothelial nitric oxide synthase (NOS3) produces nitric oxide which is a mediator of cytotoxic effects potentially associated with breast cancer. We evaluated the role of genetic polymorphisms of NOS3 in breast cancer etiology, in a case-control study conducted in Korea. We recruited 1,385 eligible patients with histologically confirmed incident breast cancer cases and 968 hospital-based controls. Two potentially functional NOS3 polymorphisms in the promoter region (-786T > C) and exon 7 (894G > T, Glu298Asp) were genotyped and individual haplotypes were estimated. Odds ratios (ORs) and 95% confidential intervals (95% CIs) were calculated by unconditional logistic regression, adjusting for age, body mass index, education, family history of breast cancer in first and second degree relatives, age at first full-term pregnancy and parity. There was no overall association between the -786T > C or 894G > T genotype and breast cancer risk. However, the -786C allele was marginally associated with decreased risk for invasive breast cancer with lymph node involvement (OR = 0.76, 95% CI = 0.56-1.04). And, compared to TG-TG carriers, all other haplotype pairs were significantly associated with invasive breast cancer with lymph node involvement (OR = 0.77, 95% CI = 0.59-0.99). Our results suggest that genetic polymorphisms in NOS3 modify individual susceptibility to invasive breast cancer with lymph node involvement in Korean women.
ISSN
0167-6806 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17262178

http://hdl.handle.net/10371/15618
DOI
https://doi.org/10.1007/s10549-007-9506-y
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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