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Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement

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dc.contributor.authorLee, Kyoung-Mu-
dc.contributor.authorChoi, Ji-Yeob-
dc.contributor.authorLee, Jong Eun-
dc.contributor.authorNoh, Dong-Young-
dc.contributor.authorAhn, Sei-Hyun-
dc.contributor.authorHan, Wonshik-
dc.contributor.authorYoo, Keun-Young-
dc.contributor.authorHayes, Richard B-
dc.contributor.authorKang, Daehee-
dc.date.accessioned2009-11-26T02:12:08Z-
dc.date.available2009-11-26T02:12:08Z-
dc.date.issued2007-01-31-
dc.identifier.citationBreast Cancer Res Treat. 2007 Dec;106(3):433-8. Epub 2007 Jan 30en
dc.identifier.issn0167-6806 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17262178-
dc.identifier.urihttps://hdl.handle.net/10371/15618-
dc.description.abstractEndothelial nitric oxide synthase (NOS3) produces nitric oxide which is a mediator of cytotoxic effects potentially associated with breast cancer. We evaluated the role of genetic polymorphisms of NOS3 in breast cancer etiology, in a case-control study conducted in Korea. We recruited 1,385 eligible patients with histologically confirmed incident breast cancer cases and 968 hospital-based controls. Two potentially functional NOS3 polymorphisms in the promoter region (-786T > C) and exon 7 (894G > T, Glu298Asp) were genotyped and individual haplotypes were estimated. Odds ratios (ORs) and 95% confidential intervals (95% CIs) were calculated by unconditional logistic regression, adjusting for age, body mass index, education, family history of breast cancer in first and second degree relatives, age at first full-term pregnancy and parity. There was no overall association between the -786T > C or 894G > T genotype and breast cancer risk. However, the -786C allele was marginally associated with decreased risk for invasive breast cancer with lymph node involvement (OR = 0.76, 95% CI = 0.56-1.04). And, compared to TG-TG carriers, all other haplotype pairs were significantly associated with invasive breast cancer with lymph node involvement (OR = 0.77, 95% CI = 0.59-0.99). Our results suggest that genetic polymorphisms in NOS3 modify individual susceptibility to invasive breast cancer with lymph node involvement in Korean women.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBreast Neoplasms/*genetics/pathologyen
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHumansen
dc.subjectLymphatic Metastasisen
dc.subjectMiddle Ageden
dc.subjectNitric Oxide Synthase Type III/*geneticsen
dc.subjectRisken
dc.subjectPolymorphism, Genetic-
dc.titleGenetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvementen
dc.typeArticleen
dc.contributor.AlternativeAuthor이경무-
dc.contributor.AlternativeAuthor최지엽-
dc.contributor.AlternativeAuthor이종은-
dc.contributor.AlternativeAuthor노동영-
dc.contributor.AlternativeAuthor안세현-
dc.contributor.AlternativeAuthor한원식-
dc.contributor.AlternativeAuthor유근영-
dc.contributor.AlternativeAuthor강대희-
dc.identifier.doi10.1007/s10549-007-9506-y-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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