Browse

C-reactive protein concentration in vaginal fluid as a marker for intra-amniotic inflammation/infection in preterm premature rupture of membranes

DC Field Value Language
dc.contributor.authorShim, Soon-Sup-
dc.contributor.authorRomero, Roberto-
dc.contributor.authorJun, Jong Kwan-
dc.contributor.authorMoon, Kyung Chul-
dc.contributor.authorKim, Gilja-
dc.contributor.authorYoon, Bo Hyun-
dc.date.accessioned2009-11-26T02:38:33Z-
dc.date.available2009-11-26T02:38:33Z-
dc.date.issued2006-01-05-
dc.identifier.citationJ Matern Fetal Neonatal Med. 2005 Dec;18(6):417-22.en
dc.identifier.issn1476-7058 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16390808-
dc.identifier.urihttps://hdl.handle.net/10371/15666-
dc.description.abstractOBJECTIVE: The purpose of this study was to determine whether C-reactive protein (CRP) concentrations in vaginal fluid can identify patients with intra-amniotic inflammation/infection (IAI) and predict adverse outcome in preterm premature rupture of membranes (PROM). METHODS: The study population consisted of 121 singleton pregnant women with preterm PROM (36 weeks of gestation) who had an amniocentesis and vaginal fluid collection. A Dacron polyester-tipped applicator was soaked with vaginal fluid for 10 seconds and diluted with 1 mL buffer solution. Amniotic fluid was cultured for aerobic and anaerobic bacteria, as well as mycoplasmas. Vaginal fluid CRP and amniotic fluid matrix metalloproteinase-8 (MMP-8) were determined by specific immunoassays. IAI was defined as an amniotic fluid MMP-8 concentration >23 ng/mL and/or a positive amniotic fluid culture. Nonparametric tests and survival techniques were used for statistical analysis. RESULTS: Patients with IAI had a significantly higher median vaginal fluid CRP concentration than those without IAI (median (range), 7.8 (0.1-1310.1) ng/mL vs. 1.0 (0.1-319.4) ng/mL, p < 0.005). The median amniotic fluid white blood cell (WBC) count was significantly higher in patients with a vaginal fluid CRP concentration of >10 ng/mL than in those with a lower concentration (median (range), 82.5 (0-8640) cells/mm3 vs. 2 (0->1000) cells/mm3, p < 0.001). Patients with vaginal fluid CRP concentration of >10 ng/mL had a significantly shorter sampling-to-delivery interval and higher rates of preterm delivery within five days, funisitis, and histologic chorioamnionitis than did those with a vaginal fluid CRP concentration below this cut-off. A vaginal fluid CRP cut-off of 10 ng/mL had a specificity of 89% and a sensitivity of 45% in the identification of IAI. CONCLUSION: An elevated CRP concentration in vaginal fluid collected by polyester-tipped applicator is a risk factor for intra-amniotic inflammation/infection and impending preterm delivery in preterm PROM.en
dc.language.isoen-
dc.publisherTaylor & Francisen
dc.subjectAmniocentesisen
dc.subjectAmniotic Fluid/*metabolismen
dc.subjectBiological Markers/analysisen
dc.subjectC-Reactive Protein/*analysisen
dc.subjectChorioamnionitis/*diagnosisen
dc.subjectFemaleen
dc.subjectFetal Membranes, Premature Rupture/diagnosis/*metabolismen
dc.subjectHumansen
dc.subjectPregnancyen
dc.subjectPregnancy Complications, Infectious/diagnosis/*metabolismen
dc.subjectROC Curveen
dc.subjectVagina/*chemistryen
dc.titleC-reactive protein concentration in vaginal fluid as a marker for intra-amniotic inflammation/infection in preterm premature rupture of membranesen
dc.typeArticleen
dc.contributor.AlternativeAuthor심순섭-
dc.contributor.AlternativeAuthor전종관-
dc.contributor.AlternativeAuthor문경철-
dc.contributor.AlternativeAuthor김길자-
dc.contributor.AlternativeAuthor윤보현-
dc.identifier.doi10.1080/14786430500362231-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse