S-Space College of Medicine/School of Medicine (의과대학/대학원) Family Medicine (가정의학전공) Journal Papers (저널논문_가정의학전공)
High triglyceride/HDL cholesterol ratio is associated with silent brain infarcts in a healthy population
|dc.identifier.citation||BMC Neurology. 2019 Jul 02;19(1):147||ko_KR|
Triglycerides (TG)/high-density lipoprotein (HDL) cholesterol ratio is a marker of small/dense low-density lipoprotein particles, which are closely associated with various metabolic and vascular diseases. However, the role of TG/HDL cholesterol ratio in cerebrovascular diseases has not been well studied. In this study, we evaluated the relationship between TG/HDL cholesterol ratio and the presence of silent brain infarct (SBI) in a neurologically healthy population.
We retrospectively evaluated consecutive participants in health check-ups between January 2006 and December 2013. SBI was defined as an asymptomatic, well-defined lesion with a diameter of ≥3 mm on T1- or T2-weighted images. TG/HDL cholesterol ratio was calculated after dividing absolute TG levels by absolute HDL cholesterol levels.
Of 3172 healthy participants, 263 (8.3%) had SBI lesions. In multivariate analysis, TG/HDL cholesterol ratio was independently associated with SBI (adjusted odds ratio [aOR] = 1.16, 95% confidence interval [CI] = 1.00 to 1.34, P = 0.047). This association was prominent in males (aOR = 1.23, 95% CI = 1.03 to 1.48, P = 0.021), but not in females. In the analyses of the relationships between lipid parameters and SBI lesion burden, TG/HDL cholesterol ratio was positively correlated, and total cholesterol/TG ratio was negatively correlated with SBI lesion burden, in dose-response manners (P for trend = 0.015 and 0.002, respectively).
The TG/HDL cholesterol ratio was positively associated with the prevalence of SBI in a neurologically healthy population.
|dc.subject||Silent brain infarct||ko_KR|
|dc.subject||Cerebral small vessel diseases||ko_KR|
|dc.title||High triglyceride/HDL cholesterol ratio is associated with silent brain infarcts in a healthy population||ko_KR|
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- College of Medicine/School of Medicine (의과대학/대학원)Family Medicine (가정의학전공)Journal Papers (저널논문_가정의학전공)