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A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea

Cited 106 time in Web of Science Cited 110 time in Scopus
Authors
Kim, Eu Suk; Song, Jin Su; Lee, Hye Jin; Choe, Pyoeng Gyun; Park, Kyung Hwa; Cho, Jae Hyun; Park, Wan Beom; Kim, Sung-Han; Bang, Ji-Hwan; Kim, Dong-Min; Park, Kyoung Un; Shin, Sue; Lee, Mi Suk; Choi, Hee Jung; Kim, Nam Joong; Kim, Eui-Chong; Oh, Myoung-Don; Kim, Hong Bin; Choe, Kang Won
Issue Date
2007-09-22
Publisher
Oxford University Press
Citation
J Antimicrob Chemother. 2007 Nov;60(5):1108-14. Epub 2007 Sep 20.
Keywords
AdolescentAdultAgedAged, 80 and overChildChild, PreschoolCommunity-Acquired Infections/*epidemiology/*microbiologyCross Infection/epidemiology/microbiologyFemaleHumansInfantInfant, NewbornKorea/epidemiologyMale*Methicillin ResistanceMiddle AgedStaphylococcal Infections/*epidemiology/*microbiologyStaphylococcus aureus/*drug effects
Abstract
OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA), originally restricted to hospitals, has emerged as a significant pathogen in the community. Although MRSA accounts for over 60% of S. aureus in tertiary hospitals in Korea, little is known about the epidemiology of community-associated MRSA (CA-MRSA). METHODS: From January to July 2005, a hospital laboratory-based survey was conducted in seven community-based or tertiary hospitals. The medical records and Health Insurance Review Agency databases were reviewed and MRSA isolated from patients without apparent risk factors was defined as CA-MRSA. Susceptibilities to 12 antibiotics were tested by the disc diffusion method. SCCmec typing, Panton-Valentine leucocidin (PVL) gene detection and multilocus sequence typing (MLST) were performed according to published protocols. RESULTS: Of 3,251 S. aureus, 1,900 (58.4%) were MRSA. CA-MRSA accounted for 112 (5.9%) of the MRSA. Of the 112 CA-MRSA isolates, 27 and 33 were found to be pathogens and colonizers, respectively. Fifty-two isolates from the patients with chronic otitis media were classified as 'undetermined'. Most of the 27 CA-MRSA patients had skin and soft tissue infections or acute ear infections. None of the patients died during the study period. Among 72 isolates tested, 64% were multidrug-resistant. SCCmec type IVa was the most common type among the colonizers and pathogens. On MLST analysis, ST72 was predominant, but ST5 and ST239 were prevalent in the 'undetermined' group. None possessed the PVL gene. CONCLUSIONS: Despite MRSA-endemic hospital settings, CA-MRSA infections are not common in Korea. A new clone of CA-MRSA, ST72-SCCmec type IVa without the PVL gene, is the most common form.
ISSN
0305-7453 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17884831

http://hdl.handle.net/10371/15713
DOI
https://doi.org/10.1093/jac/dkm309
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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