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A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea

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dc.contributor.authorKim, Eu Suk-
dc.contributor.authorSong, Jin Su-
dc.contributor.authorLee, Hye Jin-
dc.contributor.authorChoe, Pyoeng Gyun-
dc.contributor.authorPark, Kyung Hwa-
dc.contributor.authorCho, Jae Hyun-
dc.contributor.authorPark, Wan Beom-
dc.contributor.authorKim, Sung-Han-
dc.contributor.authorBang, Ji-Hwan-
dc.contributor.authorKim, Dong-Min-
dc.contributor.authorPark, Kyoung Un-
dc.contributor.authorShin, Sue-
dc.contributor.authorLee, Mi Suk-
dc.contributor.authorChoi, Hee Jung-
dc.contributor.authorKim, Nam Joong-
dc.contributor.authorKim, Eui-Chong-
dc.contributor.authorOh, Myoung-Don-
dc.contributor.authorKim, Hong Bin-
dc.contributor.authorChoe, Kang Won-
dc.date.accessioned2009-11-26T03:00:59Z-
dc.date.available2009-11-26T03:00:59Z-
dc.date.issued2007-09-22-
dc.identifier.citationJ Antimicrob Chemother. 2007 Nov;60(5):1108-14. Epub 2007 Sep 20.en
dc.identifier.issn0305-7453 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17884831-
dc.identifier.urihttps://hdl.handle.net/10371/15713-
dc.description.abstractOBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA), originally restricted to hospitals, has emerged as a significant pathogen in the community. Although MRSA accounts for over 60% of S. aureus in tertiary hospitals in Korea, little is known about the epidemiology of community-associated MRSA (CA-MRSA). METHODS: From January to July 2005, a hospital laboratory-based survey was conducted in seven community-based or tertiary hospitals. The medical records and Health Insurance Review Agency databases were reviewed and MRSA isolated from patients without apparent risk factors was defined as CA-MRSA. Susceptibilities to 12 antibiotics were tested by the disc diffusion method. SCCmec typing, Panton-Valentine leucocidin (PVL) gene detection and multilocus sequence typing (MLST) were performed according to published protocols. RESULTS: Of 3,251 S. aureus, 1,900 (58.4%) were MRSA. CA-MRSA accounted for 112 (5.9%) of the MRSA. Of the 112 CA-MRSA isolates, 27 and 33 were found to be pathogens and colonizers, respectively. Fifty-two isolates from the patients with chronic otitis media were classified as 'undetermined'. Most of the 27 CA-MRSA patients had skin and soft tissue infections or acute ear infections. None of the patients died during the study period. Among 72 isolates tested, 64% were multidrug-resistant. SCCmec type IVa was the most common type among the colonizers and pathogens. On MLST analysis, ST72 was predominant, but ST5 and ST239 were prevalent in the 'undetermined' group. None possessed the PVL gene. CONCLUSIONS: Despite MRSA-endemic hospital settings, CA-MRSA infections are not common in Korea. A new clone of CA-MRSA, ST72-SCCmec type IVa without the PVL gene, is the most common form.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectCommunity-Acquired Infections/*epidemiology/*microbiologyen
dc.subjectCross Infection/epidemiology/microbiologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectKorea/epidemiologyen
dc.subjectMaleen
dc.subject*Methicillin Resistanceen
dc.subjectMiddle Ageden
dc.subjectStaphylococcal Infections/*epidemiology/*microbiologyen
dc.subjectStaphylococcus aureus/*drug effectsen
dc.titleA survey of community-associated methicillin-resistant Staphylococcus aureus in Koreaen
dc.typeArticleen
dc.contributor.AlternativeAuthor김의석-
dc.contributor.AlternativeAuthor송진수-
dc.contributor.AlternativeAuthor이혜진-
dc.contributor.AlternativeAuthor최평균-
dc.contributor.AlternativeAuthor박경화-
dc.contributor.AlternativeAuthor조재현-
dc.contributor.AlternativeAuthor박완범-
dc.contributor.AlternativeAuthor김성한-
dc.contributor.AlternativeAuthor방지환-
dc.contributor.AlternativeAuthor김동민-
dc.contributor.AlternativeAuthor박경운-
dc.contributor.AlternativeAuthor신수-
dc.contributor.AlternativeAuthor이미숙-
dc.contributor.AlternativeAuthor최희정-
dc.contributor.AlternativeAuthor김남중-
dc.contributor.AlternativeAuthor김의종-
dc.contributor.AlternativeAuthor오명돈-
dc.contributor.AlternativeAuthor김홍빈-
dc.contributor.AlternativeAuthor최강원-
dc.identifier.doi10.1093/jac/dkm309-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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