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A comparison of two cyclosporine dosage regimens for the treatment of severe psoriasis
Cited 20 time in
Web of Science
Cited 24 time in Scopus
- Authors
- Issue Date
- 2007-09-14
- Publisher
- Taylor & Francis
- Citation
- J Dermatolog Treat. 2007;18(5):286-90.
- Keywords
- Adult ; Aged ; Cyclosporine/*administration & dosage/adverse effects ; Drug Administration Schedule ; Drug Dosage Calculations ; Female ; Humans ; Immunosuppressive Agents/*administration & dosage/adverse effects ; Male ; Middle Aged ; Psoriasis/*drug therapy/pathology ; Severity of Illness Index ; Skin/pathology ; Treatment Outcome
- Abstract
- BACKGROUND: Few reports have been issued which compare the efficacy and tolerability of cyclosporine dose adjustments before 12 weeks of treatment. OBJECTIVE: To compare the efficacy and tolerability of two different dosage regimens of cyclosporine in severe psoriasis. METHODS: This 12-week, prospective, open-label study included 61 severe psoriasis patients. Patients were assigned to a 2.5 mg/kg per day starting dose and an increasing regimen ('standard regimen') or a 5.0 mg/kg per day starting dose and a decreasing regimen ('step-down regimen') group. The end point included 50% and 75% reductions in Psoriasis Area and Severity Index (PASI) scores. Adverse events were also evaluated. RESULTS: According to a 50% PASI reduction (PASI 50), the response rate at 12 weeks was similar for two groups. The percentage of patients achieving a 75% PASI reduction (PASI 75) at 12 weeks was higher in the step-down regimen group. The mean time to PASI 50 or PASI 75 was shorter in the step-down regimen group. No difference was found between the two groups in terms of the number of patients with adverse events requiring intervention. CONCLUSION: This study suggests that the 'step-down' cyclosporine regimen offers an effective and safe therapeutic option for the management of severe psoriasis.
- ISSN
- 0954-6634 (Print)
- Language
- English
- URI
- http://www.informaworld.com/smpp/content~db=all?content=10.1080/09546630701418747
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17852632
https://hdl.handle.net/10371/15727
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