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항결핵 약제 유발 간독성과 혈중 항결핵 약제 농도의 상관관계
Drug induced hepatotoxicity of anti-tuberculosis drug and their serum levels

DC Field Value Language
dc.contributor.advisor이재호-
dc.contributor.author정인아-
dc.date.accessioned2019-07-09T17:43:08Z-
dc.date.available2019-07-09T17:43:08Z-
dc.date.issued2011-02-
dc.identifier.other000000030457-
dc.identifier.urihttps://hdl.handle.net/10371/158312-
dc.identifier.urihttp://dcollection.snu.ac.kr:80/jsp/common/DcLoOrgPer.jsp?sItemId=000000030457ko_KR
dc.description학위논문 (석사)-- 서울대학교 대학원 : 의학과 내과학전공, 2011.2. 이재호.-
dc.format.extentv, 20 장-
dc.language.isokor-
dc.publisher서울대학교 대학원-
dc.subject결핵-
dc.subject간독성-
dc.subject약제모니터링-
dc.subjectBackgrounds: Hepatotoxicity is one of the most common adverse reaction of anti-tuberculosis(TB) treatment. Relatively little is known about hepatotoxicity and their serum levels of anti-TB drugs. Objective: To investigate the incidence of drug-induced hepatotoxicity (DIH) caused by anti-TB drugs and to identify the association of DIH and serum anti-tuberculosis drug concentrations. Methods: Serum levels of isoniazid (INH)-
dc.subjectrifampicin (RMP)-
dc.subjectethambutol (EMB)-
dc.subjectpyrazinamide (PZA) were analysed by blood sample 2 hours after drug ingestion in patients on anti-TB treatment. DIH was investigated retrospectively and defined when liver enzyme exceed three times upper limit of normal. We compared serum drug level and other clinical factors between hepatotoxicity group and no-hepatotoxicity group. Patients with HIV co-infection-
dc.subjectacute viral hepatitis-
dc.subjectchronic liver disease-
dc.subjectmalabsorption were excluded. Results: Between June 2006 and Feb 2010-
dc.subject195 patients were included in the analysis. The median age of 195 patients(men 60%) was 46 yrs(range 16-92). Hepatotoxicity occurred in 19(9.7%) patients and their mean AST-
dc.subjectALT was 245-
dc.subject244. Among 19 patients-
dc.subjectPZA related and INH or RMP related hepatotoxicity was estimated in 9 and 8 patients respectively. However-
dc.subjectserum levels of four anti-TB drugs did not differ statistically between hepatotoxicity and no-hepatotoxicity group. Age-
dc.subjectsex-
dc.subjectpast history of TB-
dc.subjectbody mass index(BMI) also did not show statistical difference. Conclusion: There were relatively small number of patients whose drug level exceeds reference range and serum drug level did not show relevance to DIH.-
dc.title항결핵 약제 유발 간독성과 혈중 항결핵 약제 농도의 상관관계-
dc.title.alternativeDrug induced hepatotoxicity of anti-tuberculosis drug and their serum levels-
dc.typeThesis-
dc.typeDissertation-
dc.description.degreeMaster-
dc.contributor.affiliation의학과 내과학전공-
dc.date.awarded2011-02-
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Master's Degree_의학과)
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