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항결핵 약제 유발 간독성과 혈중 항결핵 약제 농도의 상관관계 : Drug induced hepatotoxicity of anti-tuberculosis drug and their serum levels
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이재호 | - |
dc.contributor.author | 정인아 | - |
dc.date.accessioned | 2019-07-09T17:43:08Z | - |
dc.date.available | 2019-07-09T17:43:08Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.other | 000000030457 | - |
dc.identifier.uri | https://hdl.handle.net/10371/158312 | - |
dc.identifier.uri | http://dcollection.snu.ac.kr:80/jsp/common/DcLoOrgPer.jsp?sItemId=000000030457 | ko_KR |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의학과 내과학전공, 2011.2. 이재호. | - |
dc.format.extent | v, 20 장 | - |
dc.language.iso | kor | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | 결핵 | - |
dc.subject | 간독성 | - |
dc.subject | 약제모니터링 | - |
dc.subject | Backgrounds: Hepatotoxicity is one of the most common adverse reaction of anti-tuberculosis(TB) treatment. Relatively little is known about hepatotoxicity and their serum levels of anti-TB drugs. Objective: To investigate the incidence of drug-induced hepatotoxicity (DIH) caused by anti-TB drugs and to identify the association of DIH and serum anti-tuberculosis drug concentrations. Methods: Serum levels of isoniazid (INH) | - |
dc.subject | rifampicin (RMP) | - |
dc.subject | ethambutol (EMB) | - |
dc.subject | pyrazinamide (PZA) were analysed by blood sample 2 hours after drug ingestion in patients on anti-TB treatment. DIH was investigated retrospectively and defined when liver enzyme exceed three times upper limit of normal. We compared serum drug level and other clinical factors between hepatotoxicity group and no-hepatotoxicity group. Patients with HIV co-infection | - |
dc.subject | acute viral hepatitis | - |
dc.subject | chronic liver disease | - |
dc.subject | malabsorption were excluded. Results: Between June 2006 and Feb 2010 | - |
dc.subject | 195 patients were included in the analysis. The median age of 195 patients(men 60%) was 46 yrs(range 16-92). Hepatotoxicity occurred in 19(9.7%) patients and their mean AST | - |
dc.subject | ALT was 245 | - |
dc.subject | 244. Among 19 patients | - |
dc.subject | PZA related and INH or RMP related hepatotoxicity was estimated in 9 and 8 patients respectively. However | - |
dc.subject | serum levels of four anti-TB drugs did not differ statistically between hepatotoxicity and no-hepatotoxicity group. Age | - |
dc.subject | sex | - |
dc.subject | past history of TB | - |
dc.subject | body mass index(BMI) also did not show statistical difference. Conclusion: There were relatively small number of patients whose drug level exceeds reference range and serum drug level did not show relevance to DIH. | - |
dc.title | 항결핵 약제 유발 간독성과 혈중 항결핵 약제 농도의 상관관계 | - |
dc.title.alternative | Drug induced hepatotoxicity of anti-tuberculosis drug and their serum levels | - |
dc.type | Thesis | - |
dc.type | Dissertation | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 의학과 내과학전공 | - |
dc.date.awarded | 2011-02 | - |
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