Browse

Restoration of erectile capacity in normotensive aged rats by modulation of angiotensin receptor type 1

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors

Park, Kwanjin; Shin, Jae Wook; Oh, Jin Kyu; Ryu, Kyong Shin; Kim, Soo Woong; Paick, Jae-Seung

Issue Date
2004-12-22
Publisher
Published for the American Society of Andrology, inc. by the J.B.Lippincott Co
Citation
J Androl. 2005 Jan-Feb;26(1):123-8.
Keywords
AnimalsAntihypertensive Agents/pharmacologyApomorphine/pharmacologyBlood PressureBlotting, WesternDopamine Agonists/pharmacologyErectile Dysfunction/*drug therapy/etiologyLipid Peroxidation/drug effectsLosartan/pharmacologyMalePenile Erection/drug effects/*physiologyRatsRats, Sprague-DawleyReceptor, Angiotensin, Type 1/drug effects/*metabolismRenin-Angiotensin System/drug effects/*physiologyAging
Abstract
We investigated the effects of systemic modulation of angiotensin 2 on the erectile dysfunction of aged rats. Young and aged (18 months old) male Sprague-Dawley rats were either treated with daily administration of losartan (angiotensin type 1 receptor antagonist, 30 mg/kg/d PO) or the drug vehicle (control) for 4 weeks (n=6 in each group). We monitored the intracavernosal pressure (ICP) after administration of apomorphine (100 microg/kg), and we measured the degree of lipid peroxidation of corpus cavernosum and the cavernosal protein expression by an immunoblot technique. Compared to the control young rats, the control aged rats showed significant impairment of erectile function; however, losartan treatment effectively restored the erectile function of aged rat to a level similar to that of young rats. Despite the systemic pressure-lowering effect of the drug, the peak ICP was not significantly reduced; rather, the ICP/systemic arterial pressure (SAP) was increased by the losartan treatment. Measurement of lipid peroxidation revealed the fact that the drug was effective in diminishing oxidative stress. While the losartan treatment significantly enhanced the expression of endothelial nitric oxide synthase (eNOS), it had no effect on the expression of transforming growth factor (TGF)-beta1. The results obtained indicated that alteration of the renin-angiotensin system might be implicated in the erectile dysfunction of elderly males, and modulation of this system may be of great therapeutic value.
ISSN
0196-3635 (Print)
Language
Korean
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15611576

https://hdl.handle.net/10371/15907
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse