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Paclitaxel/platinum-based perioperative chemotherapy and surgery in stage IIIA non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Choi, In Sil | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Kwon, Jung Hye | - |
dc.contributor.author | Kim, Sang-Il | - |
dc.contributor.author | Park, Sook Ryun | - |
dc.contributor.author | Bak, Ji-Youn | - |
dc.contributor.author | Kim, Jee Hyun | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Kim, Young Tae | - |
dc.contributor.author | Kim, Tae You | - |
dc.contributor.author | You, Chul-Kyu | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Sung, Sook Whan | - |
dc.contributor.author | Park, Charn Il | - |
dc.contributor.author | Kim, Noe Kyeong | - |
dc.date.accessioned | 2009-11-26T05:25:47Z | - |
dc.date.available | 2009-11-26T05:25:47Z | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2005-01 | - |
dc.identifier.citation | Japanese Journal of Clinical Oncology, Vol.35 No.1, pp.6-12 | - |
dc.identifier.issn | 0368-2811 | - |
dc.identifier.other | 95323 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15938 | - |
dc.description.abstract | Objective: The objectives of the present study were to assess the efficacy and tolerability of perioiperative paclitaxel/platinum-based chemotherapy and surgery in patients with stage IIIA clinical N2 (cN2) non-small cell lung cancer (NSCLC). Methods: Clinical N2 was defined as either > 15 mm or > 10 mm and multiple nodes on computed tomography (CT) scan. Thirty-four chemotherapy-naive patients with stage IIIA cN2 received preoperative paclitaxel/cisplatin for two cycles and then underwent surgery. The treatment with paclitaxel/carboplatin was repeated for three cycles after the operation. Results: Of the 34 patients, none achieved a complete response (CR) and 22 achieved a partial response (PR), resulting in a response rate of 65%. Among 29 patients (85%) who had received thoracotomy, 25 (74%) underwent complete resection. Two pathological CRs were observed and mediastinal nodes were free of tumor in 21 %. Grade 3-4 toxicity was uncommon and treatment-related mortality was not observed. The median time to progression (TTP) was 12.1 months [95% confidence interval (CI) 8.3-15.9 months] and median overall survival (OS) was 23.6 months (95% CI 17.7-30.2 months). Conclusions: Paclitaxel/platinum-based perioperative chemotherapy and surgery for patients with stage IIIA cN2 NSCLC is effective and well tolerated. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | - |
dc.title | Paclitaxel/platinum-based perioperative chemotherapy and surgery in stage IIIA non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1093/jjco/hyi008 | - |
dc.citation.journaltitle | Japanese Journal of Clinical Oncology | - |
dc.identifier.wosid | 000227651100002 | - |
dc.identifier.scopusid | 2-s2.0-14944386981 | - |
dc.citation.endpage | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 6 | - |
dc.citation.volume | 35 | - |
dc.identifier.sci | 000227651100002 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Kim, Tae You | - |
dc.contributor.affiliatedAuthor | You, Chul-Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Young Whan | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Sung, Sook Whan | - |
dc.contributor.affiliatedAuthor | Park, Charn Il | - |
dc.contributor.affiliatedAuthor | Kim, Noe Kyeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ONCOLOGY-GROUP TRIAL | - |
dc.subject.keywordPlus | PREOPERATIVE CHEMOTHERAPY | - |
dc.subject.keywordPlus | PHASE-II | - |
dc.subject.keywordPlus | INDUCTION CHEMOTHERAPY | - |
dc.subject.keywordPlus | RANDOMIZED-TRIAL | - |
dc.subject.keywordPlus | BRONCHOGENIC-CARCINOMA | - |
dc.subject.keywordPlus | NEOADJUVANT THERAPY | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | PLUS CARBOPLATIN | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordAuthor | neoadjuvant chemotherapy | - |
dc.subject.keywordAuthor | non-small cell lung cancer | - |
dc.subject.keywordAuthor | paclitaxel | - |
dc.subject.keywordAuthor | platinum | - |
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