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Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies

Cited 33 time in Web of Science Cited 36 time in Scopus

Lee, Sang-Ah; Lee, Kyoung-Mu; Park, Sue Kyung; Choi, Ji-Yeob; Kim, Bongcheol; Nam, Jinwu; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Kang, Daehee

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Springer Verlag
Breast Cancer Res Treat. 2007 May;103(1):71-6. Epub 2006 Oct 25
Asian Continental Ancestry Group/*geneticsBreast Neoplasms/epidemiology/*geneticsCase-Control StudiesDNA-Binding Proteins/*geneticsEuropean Continental Ancestry Group/geneticsFemaleGenetic Predisposition to Disease/epidemiology/*geneticsHumansKorea/epidemiologyMiddle AgedPolymorphism, Genetic
To evaluate the relationship of genetic polymorphism in XRCC3 Thr(241)Met and the risk of breast cancer, a hospital-based case-control study was conducted in Korea. Histologically confirmed breast cancer cases (n = 574) and controls (n = 502) with no present or previous history of cancer were recruited from several teaching hospitals in Seoul during 1995-2001. Information on demographic characteristics and other information were collected by interviewed questionnaire. Genetic polymorphisms of XRCC3 Thr(241)Met (C > T) was determined by single base extention assay. The frequency of Thr/Thr, Thr/Met, and Met/Met genotype were 89.4, 10.4, 0.2% in cases and 92.3, 7.7, 0.0% in controls, respectively. Genotype distribution in controls fit well to the Hardy-Weinberg equilibrium (P = 0.74). XRCC3 codon 241 Thr/Met or Met/Met genotype moderately increased the risk of breast cancer (OR = 1.4, 95% CI: 0.87-2.33), but not significant in this study. In the results of meta-analysis using twelve reports, however, Thr/Met or Met/Met genotype increased the risk of breast cancer (OR = 1.08, 95%CI: 1.00-1.17). In conclusion, although the genetic polymorphism of XRCC3 Thr(241)Met was unlikely to have a substantial overall association in Korean women, the meta-analysis of studies, including ours, provided that Thr/Met and Met/Met was weakly increased the risk of breast cancer compare to Thr/Thr genotype.
0167-6806 (Print)
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