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Combination therapy of vitamin C and thiamine for septic shock in a multicentre, double-blind, randomized, controlled study (ATESS): study protocol for a randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | Hwang, Sung Yeon | - |
dc.contributor.author | Park, Jong Eun | - |
dc.contributor.author | Jo, Ik Joon | - |
dc.contributor.author | Kim, Seonwoo | - |
dc.contributor.author | Chung, Sung Phil | - |
dc.contributor.author | Kong, Taeyoung | - |
dc.contributor.author | Shin, Jonghwan | - |
dc.contributor.author | Lee, Hui Jai | - |
dc.contributor.author | You, Kyoung Min | - |
dc.contributor.author | Jo, You Hwan | - |
dc.contributor.author | Kim, Doyun | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Kim, Taegyun | - |
dc.contributor.author | Kim, Won Young | - |
dc.contributor.author | Kim, Youn-Jung | - |
dc.contributor.author | Ryoo, Seung Mok | - |
dc.contributor.author | Choi, Sung-Hyuk | - |
dc.contributor.author | Shin, Tae Gun | - |
dc.date.accessioned | 2019-07-22T07:57:42Z | - |
dc.date.available | 2019-07-22T16:59:35Z | - |
dc.date.issued | 2019-07-11 | - |
dc.identifier.citation | Trials. 20(1):420 | ko_KR |
dc.identifier.issn | 1745-6215 | - |
dc.identifier.uri | https://hdl.handle.net/10371/160393 | - |
dc.description.abstract | Background
Septic shock is a life-threatening condition with underlying circulatory and cellular/metabolic abnormalities. Vitamin C and thiamine are potential candidates for adjunctive therapy; they are expected to improve outcomes based on recent experimental and clinical research. The aim of the Ascorbic Acid and Thiamine Effect in Septic Shock (ATESS) trial is to evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients with septic shock. Methods This study is a randomized, double-blind, placebo-controlled, multicentre trial in adult patients with septic shock recruited from six emergency departments in South Korea. Patients will be randomly allocated into the treatment or control group (1:1 ratio), and we will recruit 116 septic shock patients (58 per group). For the treatment group, vitamin C (50 mg/kg) and thiamine (200 mg) will be mixed in 50 ml of 0.9% saline and administered intravenously every 12 h for a total of 48 h. For the placebo group, an identical volume of 0.9% saline will be administered in the same manner. The primary outcome is the delta Sequential Organ Failure Assessment (SOFA) score (ΔSOFA = initial SOFA at enrolment – follow-up SOFA after 72 h). Discussion This trial will provide valuable evidence about the effectiveness of vitamin C and thiamine therapy for septic shock. If effective, this therapy might improve survival and become one of the main therapeutic adjuncts for patients with septic shock. Trial registration ClinicalTrials.gov, NCT03756220. Registered on 5 December 2018. | ko_KR |
dc.description.sponsorship | This work was supported by a National Research Foundation of Korea grant funded by the Korean government (No. 2018R1C1B6006821). The government did not have any role in the study design; collection, management, analysis, and interpretation of data; writing of the report; and the decision to submit the report for publication. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Sepsis | ko_KR |
dc.subject | Septic shock | ko_KR |
dc.subject | Thiamine | ko_KR |
dc.subject | Vitamin C | ko_KR |
dc.subject | Resuscitation | ko_KR |
dc.title | Combination therapy of vitamin C and thiamine for septic shock in a multicentre, double-blind, randomized, controlled study (ATESS): study protocol for a randomized controlled trial | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 황성연 | - |
dc.contributor.AlternativeAuthor | 박정은 | - |
dc.contributor.AlternativeAuthor | 조익준 | - |
dc.contributor.AlternativeAuthor | 김선우 | - |
dc.contributor.AlternativeAuthor | 정성필 | - |
dc.contributor.AlternativeAuthor | 공태영 | - |
dc.contributor.AlternativeAuthor | 신종환 | - |
dc.contributor.AlternativeAuthor | 이휘재 | - |
dc.contributor.AlternativeAuthor | 유경민 | - |
dc.contributor.AlternativeAuthor | 조유환 | - |
dc.contributor.AlternativeAuthor | 김도윤 | - |
dc.contributor.AlternativeAuthor | 서길준 | - |
dc.contributor.AlternativeAuthor | 김태균 | - |
dc.contributor.AlternativeAuthor | 김원영 | - |
dc.contributor.AlternativeAuthor | 김연정 | - |
dc.contributor.AlternativeAuthor | 류승목 | - |
dc.contributor.AlternativeAuthor | 최성혁 | - |
dc.contributor.AlternativeAuthor | 신태건 | - |
dc.identifier.doi | 10.1186/s13063-019-3542-x | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2019-07-15T13:14:06Z | - |
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