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Combined low dose cyclosporine and prednisone down-regulate natural killer cell-like effector functions of CD8brightCD56+ T cells in patients with active Behcet uveitis
Cited 4 time in
Web of Science
Cited 5 time in Scopus
- Authors
- Issue Date
- 2006-09-24
- Publisher
- Taylor & Francis
- Citation
- Ocul Immunol Inflamm. 2006 Oct;14(5):267-75.
- Keywords
- Adult ; Antigens, CD56/*immunology ; Behcet Syndrome/drug therapy/*immunology ; CD8-Positive T-Lymphocytes/*physiology ; Cyclosporine/administration & dosage ; Cytotoxicity Tests, Immunologic ; Down-Regulation/*drug effects ; Drug Therapy, Combination ; Female ; Flow Cytometry ; Humans ; Immunosuppressive Agents/*administration & dosage ; Killer Cells, Natural/*immunology ; Male ; Membrane Glycoproteins/metabolism ; Middle Aged ; Perforin ; Phenotype ; Pore Forming Cytotoxic Proteins/metabolism ; Prednisone/administration & dosage ; Prospective Studies ; Receptors, CCR5/metabolism ; Receptors, Interleukin-8A/metabolism
- Abstract
- PURPOSE: To investigate the changes of effector-related phenotypic markers and the natural killer (NK)-like effector functions of CD8(bright)CD56+ T cells in patients with Behcet uveitis after combined cyclosporine and prednisone (Cs/Pd) treatment. METHODS: Ten patients with active Behcet panuveitis and 10 healthy controls were prospectively recruited in this study. The effector-related surface markers (CD27, CD62L, CD11b, HLA-DR, CD94, NKG2D), chemokine receptors (CXCR1, CXCR3, CCR4, CCR5), and intracellular perforin of circulating CD8(bright)CD56+ T cells were determined by flow cytometric analysis before and after two months' treatment. NK-like cytotoxicity of ex vivo CD8(bright)CD56+ T cells against K562 was measured by standard 51Cr release assay. RESULTS: The expression levels of effector-related molecules on CD8(bright)CD56+ T cells normalized after treatment. The expression levels of CXCR1 and CCR5 were down-regulated on CD8(bright)CD56+ T cells after treatment. The amounts of preformed intracellular perforin of CD8(bright)CD56+ T cells were reduced to the normal levels. Furthermore, the NK-like cytolytic capacities of CD8(bright)CD56+ T cells were decreased after treatment. CONCLUSIONS: Our results suggest that the combined Cs/Pd treatments in active Behcet uveitis may downregulate the NK-like effector functions of CD8(bright)CD56+ T cells.
- ISSN
- 0927-3948 (Print)
- Language
- English
- URI
- http://www.informaworld.com/smpp/content~db=all?content=10.1080/09273940600966616
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17056460
https://hdl.handle.net/10371/16150
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