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Clinical outcomes of muscle invasive bladder Cancer according to the BASQ classification

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Yuk, Hyeong Dong; Jeong, Chang Wook; Kwak, Cheol; Kim, Hyeon Hoe; Moon, Kyung Chul; Ku, Ja Hyeon
Issue Date
2019-09-09
Publisher
BioMed Central
Citation
BMC Cancer, 19(1):897
Keywords
Basal cellImmunohistochemistryMolecular subtypeNeoplasm metastasisSquamous cellUrinary bladder neoplasms
Abstract
Background
We evaluated the clinical efficacy and prognosis of muscle-invasive bladder cancer according to the basal/squamous-like (BASQ) classification system based on immunohistochemical staining [CK5/6(+), CK14(+), GATA3(−), and FOXA1(−)].

Methods
One hundred patients diagnosed with muscle-invasive bladder cancer (cT2-4 N0-3 M0) were included in the study. All patients underwent radical cystectomy after transurethral removal of bladder tumor. Immunostaining was performed for CK5/6, CK14, FOXA1, and GATA3 antibodies on tissue microarray slides, and expression patterns were quantitatively analyzed using a scanning program.

Results
The median follow-up time was 77.4 (interquartile range: 39–120.9) months. The mean age of the patients was 65.1 ± 11.2 years. FOXA1 or CK14 expression greater than 1% was respectively positively and negatively correlated with overall survival (OS; p = 0.011 and p = 0.042, respectively), cancer-specific survival (CSS; p = 0.050 for both), and recurrence-free survival (RFS; p = 0.018 and p = 0.040, respectively). For CK5/6+ and GATA3- or FOXA1- expression, 10% CK5/6+ cells were negatively correlated with OS (p = 0.032 and p = 0.039, respectively) and with RFS in combination with FOXA1- only (p = 0.050).

Conclusions
In this study, CK14 expression was associated with a poor prognosis. The new classification system of bladder cancer based on molecular characteristics is expected to helpful tool for the establishment of personalized treatment strategies and associated prediction of therapeutic responses.
ISSN
1471-2407
Language
English
URI
http://hdl.handle.net/10371/162641
DOI
https://doi.org/10.1186/s12885-019-6042-1
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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