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Decrease in glucose transporter 1 levels and translocation of glucose transporter 3 in the dentate gyrus of C57BL/6 mice and gerbils with aging

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dc.contributor.authorLee, Kwon Young-
dc.contributor.authorYoo, Dae Young-
dc.contributor.authorJung, Hyo Young-
dc.contributor.authorBaek, Loktam-
dc.contributor.authorLee, Hangyul-
dc.contributor.authorKwon, Hyun Jung-
dc.contributor.authorChung, Jin Young-
dc.contributor.authorKang, Seok Hoon-
dc.contributor.authorKim, Dae Won-
dc.contributor.authorHwang, In Koo-
dc.contributor.authorChoi, Jung Hoon-
dc.date.accessioned2020-03-04T00:57:34Z-
dc.date.available2020-03-04T10:01:41Z-
dc.date.issued2019-10-22-
dc.identifier.citationLaboratory Animal Research, 34(2):58-64ko_KR
dc.identifier.issn2233-7660-
dc.identifier.uri10.5625/lar.2018.34.2.58-
dc.identifier.urihttp://hdl.handle.net/10371/164402-
dc.description.abstractIn the present study, we compared the cell-specific expression and changes protein levels in the glucose transporters (GLUTs) 1 and 3, the major GLUTs in the mouse and gerbil brains using immuno-histochemistry and Western blot analysis. In both mouse and gerbils, GLUT1 immunoreactivity was mainly found in the blood vessels in the dentate gyrus, while GLUT3 immunoreactivity was detected in the subgranular zone and the molecular layer of the dentate gyrus. GLUT1-immunoreactivity in blood vessels and GLUT1 protein levels were significantly decreased with age in the mice and gerbils, respectively. In addition, few GLUT3-immunoreactive cells were found in the subgranular zone in aged mice and gerbils, but GLUT3-immunoreactivity was abundantly found in the polymorphic layer of dentate gyrus in mice and gerbils with a dot-like pattern. Based on the double immunofluorescence study, GLUT3-immunoreactive structures in gerbils were localized in the glial fibrillary acidic protein-immunoreactive astrocytes in the dentate gyrus. Western blot analysis showed that GLUT3 expression in the hippocampal homogenates was slightly, although not significantly, decreased with age in mice and gerbils, respectively. These results indicate that the reduction in GLUT1 in the blood vessels of dentate gyrus and GLUT3 in the subgranular zone of dentate gyrus may be associated with the decrease in uptake of glucose into brain and neuroblasts in the dentate gyrus. In addition, the expression of GLUT3 in the astrocytes in polymorphic layer of dentate gyrus may be associated with metabolic changes in glucose in aged hippocampus.ko_KR
dc.description.sponsorshipThis study was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Education, No. NRF2015R1D1A3A01020635; by 2015 Research Grant from Kangwon National University.
Conflict of interests The authors
ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectGlucose transporter-
dc.subjectaging-
dc.subjectdentate gyrus-
dc.subjectneuroblasts-
dc.subjectblood vessels-
dc.subjectastrocytes-
dc.titleDecrease in glucose transporter 1 levels and translocation of glucose transporter 3 in the dentate gyrus of C57BL/6 mice and gerbils with agingko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이권영-
dc.contributor.AlternativeAuthor유대영-
dc.contributor.AlternativeAuthor정효영-
dc.contributor.AlternativeAuthor백록담-
dc.contributor.AlternativeAuthor이한결-
dc.contributor.AlternativeAuthor권현정-
dc.contributor.AlternativeAuthor정진영-
dc.contributor.AlternativeAuthor강석훈-
dc.contributor.AlternativeAuthor김대원-
dc.contributor.AlternativeAuthor황인구-
dc.contributor.AlternativeAuthor최정훈-
dc.citation.journaltitleLaboratory Animal Researchko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2019-10-27T06:30:21Z-
dc.citation.endpage64ko_KR
dc.citation.number2ko_KR
dc.citation.startpage58ko_KR
dc.citation.volume34ko_KR
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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