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Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors

Cited 136 time in Web of Science Cited 143 time in Scopus
Authors

Lee, Jongha; Cho, Hye Rim; Cha, Gi Doo; Seo, Hyunseon; Lee, Seunghyun; Park, Chul-Kee; Kim, Jin Wook; Qiao, Shutao; Wang, Liu; Kang, Dayoung; Kang, Taegyu; Ichikawa, Tomotsugu; Kim, Jonghoon; Lee, Hakyong; Lee, Woongchan; Kim, Sanghoek; Lee, Soon-Tae; Lu, Nanshu; Hyeon, Taeghwan; Choi, Seung Hong; Kim, Dae-Hyeong

Issue Date
2019-12
Publisher
Nature Publishing Group
Citation
Nature Communications, Vol.10 No.1, p. 5205
Abstract
Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application.
ISSN
2041-1723
URI
https://hdl.handle.net/10371/164514
DOI
https://doi.org/10.1038/s41467-019-13198-y
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area Chemistry, Materials Science

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