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Early-life exposure to humidifier disinfectant determines the prognosis of lung function in children

DC Field Value Language
dc.contributor.authorCho, Hyun-Ju-
dc.contributor.authorLee, So Yeon-
dc.contributor.authorPark, Donguk-
dc.contributor.authorRyu, Seung-Hun-
dc.contributor.authorYoon, Jisun-
dc.contributor.authorJung, Sungsu-
dc.contributor.authorLee, Eun-
dc.contributor.authorYang, Song-I-
dc.contributor.authorHong, Soo-Jong-
dc.date.accessioned2020-04-01T05:22:50Z-
dc.date.available2020-04-01T14:26:22Z-
dc.date.issued2019-12-23-
dc.identifier.citationBMC Pulmonary Medicine, 19(1):261ko_KR
dc.identifier.issn1471-2466-
dc.identifier.uri10.1186/s12890-019-1028-y-
dc.identifier.urihttps://hdl.handle.net/10371/164888-
dc.description.abstractBackground
Use of humidifier disinfectants (HD) at home leads to chemical airborne exposure, causing HD associated lung injury (HDLI) with high mortality. However, the lung function in children diagnosed with HDLI is not well studied. We investigated the effect of HD exposure on lung function, prognosis, and exposure characteristics associated with the lung function phenotype in children.

Methods
Eighty-one children diagnosed with HDLI in a nationwide cohort were tested for spirometry and diffusing capacity of the lung for carbon monoxide (DLco) from July 2013 and followed up with at five time points over 2 years. The results were compared with 122 children without HD exposure as controls. Home investigation and questionnaire analysis were conducted to assess HD inhalation exposure.

Results
HDLI survivors mean percent of predicted forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and corrected DLco were significantly lower compared with the control group. On longitudinal assessment, FVC was within the normal range, but flattened, and spirometry showed a predominantly restrictive pattern. Corrected DLco did not normalize above 80% despite increasing age. The persistently low phenotype of lung function was associated with initial exposure age, especially less than 12 months of age. Higher density HD exposure during sleep and close distance between the bed and the humidifier were significantly associated with persistently low corrected DLco.

Conclusions
HD exposure affects prolonged decrement in lung function, especially DLco, particularly among children who are exposed within the first year of life. These results suggested that early-life HD exposure determines long-term prognosis of lung function in children.
ko_KR
dc.description.sponsorshipThis study was supported by the Korea Ministry of Environment (MOE) as the Environmental Health Action Program (2016001360006), and the Environmental Health Center for Hazardous Chemical Exposure funded by Ministry of Environment Republic of Korea (2019). The funding sponsors had no role in the design of the study, in the collection, analyses, or
interpretation of data, in the writing of the manuscript, or in the decision to publish the results.
ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectChemical airborne exposure-
dc.subjectHumidifier disinfectants-
dc.subjectLung function-
dc.subjectDiffusing capacity-
dc.subjectChildren-
dc.titleEarly-life exposure to humidifier disinfectant determines the prognosis of lung function in childrenko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor조현주-
dc.contributor.AlternativeAuthor이소연-
dc.contributor.AlternativeAuthor박동국-
dc.contributor.AlternativeAuthor류승훈-
dc.contributor.AlternativeAuthor유지선-
dc.contributor.AlternativeAuthor정성수-
dc.contributor.AlternativeAuthor이은-
dc.contributor.AlternativeAuthor양송이-
dc.citation.journaltitleBMC Pulmonary Medicineko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2019-12-29T04:12:18Z-
dc.citation.number1ko_KR
dc.citation.startpage261ko_KR
dc.citation.volume19ko_KR
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