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Clinical Activity, Tolerability, and Long-Term Follow-Up of Durvalumab in Patients With Advanced NSCLC

Cited 21 time in Web of Science Cited 21 time in Scopus
Authors
Antonia, Scott J.; Balmanoukian, Ani; Brahmer, Julie; Ou, Sai-Hong I.; Hellmann, Matthew D.; Kim, Sang-We; Ahn, Myung-Ju; Kim, Dong-Wan; Gutierrez, Martin; Liu, Stephen V.; Schoffski, Patrick; Jaeger, Dirk; Jamal, Rahima; Jerusalem, Guy; Lutzky, Jose; Nemunaitis, John; Calabro, Luana; Weiss, Jared; Gadgeel, Shirish; Bhosle, Jaishree; Ascierto, Paolo A.; Rebelatto, Marlon C.; Narwal, Rajesh; Liang, Meina; Xiao, Feng; Antal, Joyce; Abdullah, Shaad; Angra, Natasha; Gupta, Ashok K.; Khleif, Samir N.; Segal, Neil H.
Issue Date
2019-10
Citation
Journal of Thoracic Oncology, Vol.14 No.10, pp.1794-1806
Keywords
NSCLCSafetyEfficacyImmunotherapyDurvalumab
Abstract
Introduction: Durvalumab is a selective, high-affinity human immunoglobulin G1 monoclonal antibody that blocks programmed cell death ligand 1 (PD-L1) binding to programmed death 1. Here we report safety and clinical activity in the NSCLC cohort of a phase I/II trial that included multiple tumor types (Study 1108; NCT01693562). Methods: Patients with stage IIIB-IV NSCLC (squamous or nonsquamous) received durvalumab 10 mg/kg every 2 weeks for 12 months or until confirmed progressive disease or unacceptable toxicity. Primary objectives were safety and antitumor activity. Tumoral PD-L1 expression was assessed using the VENTANA SP263 Assay. Responses were assessed by blinded independent central review (Response Evaluation Criteria in Solid Tumors v1.1). Adverse events were graded according to National Cancer Institute's Common Terminology Criteria for Adverse Events (v4.03). Results: Of 304 patients, 79.0% were previously treated. Confirmed objective response rate was 21.8% in patients with greater than or equal to 25% PD-L1 expression and 6.4% in those with less than 25%; 25.9% in first-line patients and 12.7% in previously treated patients; and 14.0% in squamous and 16.7% in nonsquamous disease. Median overall survival was 12.4 months and median progression-free survival was 1.7 months; both were numerically longer in the PD-L1 greater than or equal to 25% group than in the PD-L1 less than 25% group (overall survival 16.4 versus 7.6 months, respectively; progression-free survival 2.6 versus 1.4 months, respectively). Treatment-related adverse events occurred in 57.2%, were grade 3/4 in 10.2%, and led to discontinuation in 5.6%. One patient (0.3%) died of treatment-related pneumonia with underlying pneumonitis. Conclusions: Durvalumab was clinically active irrespective of histology in this mostly pretreated population, with a manageable safety profile. Response rates and survival appeared to be enhanced in patients with greater tumoral PD-L1 expression. (C) 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc.
ISSN
1556-0864
URI
http://hdl.handle.net/10371/165202
DOI
https://doi.org/10.1016/j.jtho.2019.06.010
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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