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Change in PD-L1 Expression After Acquiring Resistance to Gefitinib in EGFR-Mutant Non-Small-Cell Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | Han, Jae Joon | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Koh, Jaemoon | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2020-04-27T11:11:53Z | - |
dc.date.available | 2020-04-27T11:11:53Z | - |
dc.date.created | 2018-09-04 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | Clinical Lung Cancer, Vol.17 No.4, pp.263-270 | - |
dc.identifier.issn | 1525-7304 | - |
dc.identifier.other | 49962 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165283 | - |
dc.description.abstract | Selecting patients for anti-programmed cell death 1 (PD-1) or anti-programmed death ligand 1 (PD-L1) immunotherapy by PD-L1 expression is an important issue in lung cancer. By comparing paired biopsies from patients with EGFR-mutant nonesmall-cell lung cancer (NSCLC), we found that PD-L1 expression in tumor cells markedly increased in a subset of patients after resistance to gefitinib had developed. In addition, in vitro study results suggest that some resistant mechanisms are involved in PD-L1 overexpression in gefitinibresistant NSCLC cells. Our findings suggest that repeat biopsy should be considered when using PD-L1 expression as a biomarker after EGFR inhibitor therapy. Introduction: Therapies targeting programmed cell death-1 (PD-1) and its ligand (PD-L1) have been successful in a subset of patients with nonesmall-cell lung cancer (NSCLC). PD-L1 expression in tumor tissues has been suggested as a predictive and prognostic marker. We examined the change in PD-L1 expression after gefitinib in patients with EGFR-mutant NSCLC. Materials and Methods: Paired tumor tissues were collected before and after gefitinib from 18 patients. PD-L1 expression on the tumor and immune cells was defined by the H-score of immunohistochemical staining (range, 0-300). The correlations between the change in PD-L1 expression and clinicopathologic characteristics were analyzed. Results: PD-L1 expression on tumor cells showed an increase in the median H-score from 25 to 40 (P = .067). Of the 18 patients, 7 (38.9%) had a marked increase in the median H-score (range, 80-180; group A) and 11 (61.1%) had no change in themedian H-score (0 for both scores; group B). In groups A and B, themedian progression-free survival for gefitinib was 13 and 12 months (P = .594), and the median overall survival was "not reached" and 38 months (P = .073), respectively. MET positivity by immunohistochemistry in biopsies after gefitinib therapy was significantly associated with group A (P = .028). The PD-L1 H-score by immunohistochemistry, but not by tumor cells, showed correlations with other immune cells; FOXP3(+) expression in biopsies before gefitinib use, and PD-1(+) and CD3(+) in biopsies after gefitinib therapy, respectively. Conclusion: PD-L1 expression in tumor cells markedly increased in a subset of patients after gefitinib treatment. Thus, rebiopsy should be considered when using PD-L1 expression as a biomarker. | - |
dc.language | 영어 | - |
dc.publisher | Cancer Information Group | - |
dc.title | Change in PD-L1 Expression After Acquiring Resistance to Gefitinib in EGFR-Mutant Non-Small-Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.identifier.doi | 10.1016/j.cllc.2015.11.006 | - |
dc.citation.journaltitle | Clinical Lung Cancer | - |
dc.identifier.wosid | 000378616200005 | - |
dc.identifier.scopusid | 2-s2.0-84950127361 | - |
dc.citation.endpage | 270 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 263 | - |
dc.citation.volume | 17 | - |
dc.identifier.sci | 000378616200005 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Jeon, Yoon Kyung | - |
dc.contributor.affiliatedAuthor | Chung, Doo Hyun | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | TUMOR-INFILTRATING LYMPHOCYTES | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | ANTI-PD-L1 ANTIBODY | - |
dc.subject.keywordPlus | B7-H1 EXPRESSION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordAuthor | Epidermal growth factor receptor | - |
dc.subject.keywordAuthor | Gefitinib | - |
dc.subject.keywordAuthor | NSCLC | - |
dc.subject.keywordAuthor | Programmed death receptor ligand-1 | - |
dc.subject.keywordAuthor | Tumor-infiltrating lymphocytes | - |
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