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Pretreatment neutrophil-lymphocyte ratio is not a significant prognostic factor in epidermal growth factor receptor-mutant non-small cell lung cancer patients treated with tyrosine kinase inhibitors

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dc.contributor.authorSim, Sung Hoon-
dc.contributor.authorBeom, Seung-Hoon-
dc.contributor.authorAhn, Yong-Oon-
dc.contributor.authorKeam, Bhumsuk-
dc.contributor.authorKim, Tae Min-
dc.contributor.authorLee, Se-Hoon-
dc.contributor.authorKim, Dong-Wan-
dc.contributor.authorHeo, Dae Seog-
dc.date.accessioned2020-04-27T11:16:04Z-
dc.date.available2020-04-27T11:16:04Z-
dc.date.issued2016-03-
dc.identifier.citationThoracic Cancer, Vol.7 No.2, pp.161-166-
dc.identifier.issn1759-7706-
dc.identifier.other47334-
dc.identifier.urihttps://hdl.handle.net/10371/165322-
dc.description.abstractBackgroundThe neutrophil-lymphocyte ratio (NLR) is a marker of poor prognosis in lung cancer patients. However, previous data have been based on an heterogeneous population of lung cancer patients and various treatments. In this study, we evaluate the prognostic value of NLR in an homogeneous population of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients. MethodsWe restrospectively evaluated the data of 250 NSCLC patients with EGFR mutations. All data are based on first-line treatment. ResultsAll tumors harbored in-frame deletions in exon 19 or an L858R point mutation. Eighty-five patients were treated with tyrosine kinase inhibitors (TKIs), while 165 received cytotoxic chemotherapy as first-line treatment. Multivariate survival analysis revealed that the NLR was a significant prognostic factor for first-line progression-free survival (PFS) in the chemotherapy group (hazard ratio [HR] 1.882, 95% confidence interval [CI] 1.319-2.686, P = 0.001), but was not significant in the TKI group (HR 1.239, 95% CI 0.693-2.215, P = 0.469). The response rate (RR) to first-line treatment was 76.5% in the TKI group and 29.5% in the chemotherapy group; however, the RR, according to the NLR (3 vs. > 3), was the same for both groups. ConclusionsThe NLR was a significant prognostic factor in the chemotherapy group, but it did not affect either RR or PFS in EGFR-mutant NSCLC patients treated with TKIs.-
dc.subjectEpidermal growth factor receptor mutation-
dc.subjectneutrophil lymphocyte ratio-
dc.subjectnon-small cell lung cancer-
dc.subjecttyrosine kinase inhibitor-
dc.titlePretreatment neutrophil-lymphocyte ratio is not a significant prognostic factor in epidermal growth factor receptor-mutant non-small cell lung cancer patients treated with tyrosine kinase inhibitors-
dc.typeArticle-
dc.contributor.AlternativeAuthor김동완-
dc.contributor.AlternativeAuthor허대석-
dc.identifier.doi10.1111/1759-7714.12304-
dc.citation.journaltitleThoracic Cancer-
dc.identifier.scopusid2-s2.0-84959512269-
dc.citation.endpage166-
dc.citation.number2-
dc.citation.startpage161-
dc.citation.volume7-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/1759-7714.12304-
dc.identifier.rimsid47334-
dc.identifier.sci000372281300001-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorKim, Dong-Wan-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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