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MET amplification, protein expression, and mutations in pulmonary adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Park, Seongyeol | - |
dc.contributor.author | Koh, Jaemoon | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Kim, Miso | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2020-04-27T11:18:56Z | - |
dc.date.available | 2020-04-27T11:18:56Z | - |
dc.date.created | 2018-09-28 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | Lung Cancer, Vol.90 No.3, pp.381-387 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.other | 57121 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165352 | - |
dc.description.abstract | Objectives: MET amplification, protein expression, and splice mutations at exon 14 are known to cause dysregulation of the MET/HGF pathway. Our study aimed to confirm the relationship among MET amplification, protein expression, and mutations in pulmonary adenocarcinoma. Materials and methods: MET protein expression by immunohistochemistry (IHC) and MET amplification by fluorescence in situ hybridization (FISH) were evaluated in 316 surgically resected lung adenocarcinomas. Patients were divided into 4 groups (IHC-negative/FISH-negative, IHC-negative/FISH-positive, IHC-positive/FISH-negative, and IHC-positive/FISH-positive), and 15-20 tumors in each group were randomly selected for mutation analyses to find splice mutations at exon 14. Results: An IHC score of 0-3 was found in 168 (53.2%), 71 (22.5%), 59 (18.7%), and 18 (5.7%) tumors, respectively. The mean gene copy number (GCN) was 3.56; MET FISH positivity was detected in 123 (38.9%) samples, and 26 (8.2%) of them were gene amplifications. MET amplification were significantly associated with the IHC score (P< 0.001, chi(2) test). Splice mutations were identified in only 2 (2.9%) of 70 cases. One had a MET IHC score of 2 and negative FISH without amplification; The other had a MET IHC score of 0 and positive FISH without amplification. MET IHC or FISH results were not prognostic indicators of overall survival in multivariate analysis. Conclusion: There is a significant relationship between MET amplification and protein expression, and selection of tumors with amplification using IHC was effective. However, because of its rarity, a selection strategy for mutated tumors is implausible using IHC or FISH. (c) 2015 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | MET amplification, protein expression, and mutations in pulmonary adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.identifier.doi | 10.1016/j.lungcan.2015.10.022 | - |
dc.citation.journaltitle | Lung Cancer | - |
dc.identifier.wosid | 000366873700003 | - |
dc.identifier.scopusid | 2-s2.0-84949228223 | - |
dc.citation.endpage | 387 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 381 | - |
dc.citation.volume | 90 | - |
dc.identifier.sci | 000366873700003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Jeon, Yoon Kyung | - |
dc.contributor.affiliatedAuthor | Chung, Doo Hyun | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CELL LUNG-CANCER | - |
dc.subject.keywordPlus | GENE COPY NUMBER | - |
dc.subject.keywordPlus | C-MET | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | GEFITINIB | - |
dc.subject.keywordAuthor | MET | - |
dc.subject.keywordAuthor | Gene amplification | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.subject.keywordAuthor | Mutation | - |
dc.subject.keywordAuthor | Non-small-cell lung carcinoma | - |
dc.subject.keywordAuthor | Adenocarcinoma | - |
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