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ALK Molecular Phenotype in Non-Small Cell Lung Cancer: CT Radiogenomic Characterization
DC Field | Value | Language |
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dc.contributor.author | Yamamoto, Shota | - |
dc.contributor.author | Korn, Ronald L. | - |
dc.contributor.author | Oklu, Rahmi | - |
dc.contributor.author | Migdal, Christopher | - |
dc.contributor.author | Gotway, Michael B. | - |
dc.contributor.author | Weiss, Glen J. | - |
dc.contributor.author | Iafrate, A. John | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Kuo, Michael D. | - |
dc.date.accessioned | 2020-04-27T11:25:08Z | - |
dc.date.available | 2020-04-27T11:25:08Z | - |
dc.date.created | 2020-02-19 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.citation | Radiology, Vol.272 No.2, pp.568-576 | - |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.other | 91740 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165414 | - |
dc.description.abstract | Purpose: To present a radiogenomic computed tomographic (CT) characterization of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) (ALK+). Materials and Methods: In this HIPAA-compliant institutional review board-approved retrospective study, CT studies, ALK status, and clinical-pathologic data in 172 patients with NSCLC from three institutions were analyzed. A screen of 24 CT image traits was performed in a training set of 59 patients, followed by random forest variable selection incorporating 24 CT traits plus six clinical-pathologic covariates to identify a radiogenomic predictor of ALK+ status. This predictor was then validated in an independent cohort (n = 113). Test-for-accuracy and subset analyses were performed. A similar analysis was performed to identify a biomarker associated with shorter progression-free survival (PFS) after therapy with the ALK inhibitor crizotinib. Results: ALK+ status was associated with central tumor location, absence of pleural tail, and large pleural effusion. An ALK+ radiogenomic CT status biomarker consisting of these three imaging traits with patient age of younger than 60 years showed strong discriminatory power for ALK+ status, with a sensitivity of 83.3% (15 of 18), a specificity of 77.9% (74 of 95), and an accuracy of 78.8% (89 of 113) in independent testing. The discriminatory power was particularly strong in patients with operable disease (stage IIIA or lower), with a sensitivity of 100.0% (five of five), a specificity of 88.1% (37 of 42), and an accuracy of 89.4% (42 of 47). Tumors with a disorganized vessel pattern had a shorter PFS with crizotinib therapy than tumors without this trait (11.4 vs 20.2 months, P =.041). Conclusion: ALK+ NSCLC has distinct characteristics at CT imaging that, when combined with clinical covariates, discriminate ALK+ from non-ALK tumors and can potentially identify patients with a shorter durable response to crizotinib. | - |
dc.language | 영어 | - |
dc.publisher | Radiological Society of North America | - |
dc.title | ALK Molecular Phenotype in Non-Small Cell Lung Cancer: CT Radiogenomic Characterization | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.identifier.doi | 10.1148/radiol.14140789 | - |
dc.citation.journaltitle | Radiology | - |
dc.identifier.wosid | 000340035100027 | - |
dc.identifier.scopusid | 2-s2.0-84904995349 | - |
dc.citation.endpage | 576 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 568 | - |
dc.citation.volume | 272 | - |
dc.identifier.sci | 000340035100027 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GENE-EXPRESSION PROGRAMS | - |
dc.subject.keywordPlus | ADVANCED BREAST-CANCER | - |
dc.subject.keywordPlus | TUMOR RESPONSE | - |
dc.subject.keywordPlus | SOLID TUMORS | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | CRIZOTINIB | - |
dc.subject.keywordPlus | EML4-ALK | - |
dc.subject.keywordPlus | ADENOCARCINOMAS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
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