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Clinical Course of Neuroendocrine Tumors With Different Origins (the Pancreas, Gastrointestinal Tract, and Lung)

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dc.contributor.authorKim, Su-Jung-
dc.contributor.authorKim, Jin Won-
dc.contributor.authorOh, Do-Youn-
dc.contributor.authorHan, Sae-Won-
dc.contributor.authorLee, Se-Hoon-
dc.contributor.authorKim, Dong-Wan-
dc.contributor.authorIm, Seock-Ah-
dc.contributor.authorKim, Tae-You-
dc.contributor.authorHeo, Dae Seog-
dc.contributor.authorBang, Yung-Jue-
dc.date.accessioned2020-04-27T11:32:42Z-
dc.date.available2020-04-27T11:32:42Z-
dc.date.issued2012-12-
dc.identifier.citationAmerican Journal of Clinical Oncology, Vol.35 No.6, pp.549-556-
dc.identifier.issn0277-3732-
dc.identifier.other91811-
dc.identifier.urihttps://hdl.handle.net/10371/165490-
dc.description.abstractObjectives: Neuroendocrine tumor originates from several sites. This study was conducted to reveal the differences in clinical course of neuroendocrine tumors by the origin. Methods: We reviewed data of patients diagnosed with neuroendocrine tumor between January 1996 and July 2007. Results: A total of 371 patients were enrolled [pancreas 60, gastrointestinal (GI) tract 210, lung 35, other sites 46, unknown primary sites 20]. The primary tumor site correlated with the stage (P = 0.000) and grade (P = 0.000). At diagnosis, metastasis was observed in 28.3%, 6.7%, and 2.9% of the cases in pancreatic, GI, and pulmonary neuroendocrine tumors, respectively. Grade 3 neuroendocrine tumor was observed in 7.7%, 0.5%, and 0.0% in pancreatic, GI, and pulmonary neuroendocrine tumors. Overall survival was 116.0 months (95% confidence interval, 86.9-145.1). Overall survival was 116.0 months in pancreatic neuroendocrine tumor, not reached in GI neuroendocrine tumor and 120.0 months in pulmonary neuroendocrine tumor (P = 0.024). The recurrence rate was 18.0%. It was 20.9%, 11.9%, and 2.9% in pancreatic, GI, and pulmonary neuroendocrine tumors (P = 0.062). In multivariate analysis, stage, grade, and age were prognostic for overall survival (OS). Stage, grade, and sex were prognostic for disease-free survival. Conclusions: Neuroendocrine tumors from the pancreas, GI tract, and lung showed different clinical characteristics.-
dc.subjectneuroendocrine tumor-
dc.subjectorigin-
dc.subjecttreatment outcome-
dc.subjectprognosis-
dc.titleClinical Course of Neuroendocrine Tumors With Different Origins (the Pancreas, Gastrointestinal Tract, and Lung)-
dc.typeArticle-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.1097/COC.0b013e31821dee0f-
dc.citation.journaltitleAmerican Journal of Clinical Oncology-
dc.identifier.scopusid2-s2.0-84870255588-
dc.citation.endpage556-
dc.citation.number6-
dc.citation.startpage549-
dc.citation.volume35-
dc.identifier.urlhttps://insights.ovid.com/article/00000421-201212000-00008-
dc.identifier.rimsid91811-
dc.identifier.sci000311384000008-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Dong-Wan-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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