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The relationship between response to previous systemic treatment and the efficacy of subsequent pemetrexed therapy in advanced non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Sun, Jong-Mu | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Lee, Jong Seok | - |
dc.contributor.author | Kim, Young-Whan | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2020-04-27T11:38:20Z | - |
dc.date.available | 2020-04-27T11:38:20Z | - |
dc.date.created | 2020-02-19 | - |
dc.date.created | 2020-02-19 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | Lung Cancer, Vol.68 No.3, pp.427-432 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.other | 91845 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165542 | - |
dc.description.abstract | Background: We sought to identify the relationship between response to previous systemic treatment and the efficacy of subsequent pemetrexed therapy in advanced non-small cell lung cancer (NSCLC). Patients and methods: Two hundred and fifty clinical stage IIIB or IV NSCLC patients treated with pemetrexed as a second-line or further-line treatment between April 2007 and June 2008 were analyzed retrospectively. Prior therapies were divided into four types (gemcitabine-based [G], paclitaxel-based [P] docetaxel-based [D], and EGFR tyrosine kinase inhibitor [I]). Objective response rates (ORR) and progression-free survivals (PFS) for pemetrexed therapy were analyzed according to the response outcome with each previous treatment. Results: The ORR of pemetrexed therapy was higher for patients who had achieved partial response with previous [G] therapy than others (15.0% vs. 4.3%, p = 0.02). In addition, median PFS for pemetrexed therapy was greater for responders to [G] than for nonresponders (3.0 months vs. 1.7 months, p = 0.004). The longer PFS for responders to [G] was also shown in the analysis among patients with squamous cell carcinoma (3.2 months vs. 1.7 months, p = 0.056). By univariate analyses, the variables of the responder to [G] therapy, female, adenocarcinoma, never smoking status, and ECOG performance status of 0-1 were good predictive factors for pemetrexed therapy in terms of PFS. Multivariate analysis revealed that only response to [G] had statistical significance (hazard ratio = 0.62, p = 0.006). Conclusion: Response outcome to prior [G] therapy might predict the efficacy of subsequent pemetrexed therapy in advanced NSCLC. (C) 2009 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | The relationship between response to previous systemic treatment and the efficacy of subsequent pemetrexed therapy in advanced non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1016/j.lungcan.2009.07.013 | - |
dc.citation.journaltitle | Lung Cancer | - |
dc.identifier.wosid | 000278478700017 | - |
dc.identifier.scopusid | 2-s2.0-77952543145 | - |
dc.citation.endpage | 432 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 427 | - |
dc.citation.volume | 68 | - |
dc.identifier.sci | 000278478700017 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Lee, Jong Seok | - |
dc.contributor.affiliatedAuthor | Kim, Young-Whan | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RIBONUCLEOTIDE REDUCTASE | - |
dc.subject.keywordPlus | PHASE-III | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | GEMCITABINE | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | DOCETAXEL | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | TRANSPORTS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Non-small cell lung cancer | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Pemetrexed | - |
dc.subject.keywordAuthor | Gemcitabine | - |
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