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A Phase II study of 5-fluorouracil and cisplatin systemic chemotherapy for inoperable hepatocellular carcinoma with α fetoprotein as a predictive and prognostic marker
DC Field | Value | Language |
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dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2020-04-27T11:41:14Z | - |
dc.date.available | 2020-04-27T11:41:14Z | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2008-05 | - |
dc.identifier.citation | Molecular Medicine Reports, Vol.1 No.3, pp.415-422 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.other | 95275 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165556 | - |
dc.description.abstract | The objective of this study was to evaluate the efficacy and toxicity of 5-fluorouracil and cisplatin in patients with inoperable hepatocellular carcinoma (HCC), and to evaluate the utility of alpha fetoprotein (AFP) as a marker in assessing response to systemic chemotherapy. Fifty-seven inoperable HCC patients were enrolled. The administered regimen consisted of 60 mg/m(2) cisplatin on day I followed by 1,200 mg/m(2) 5-fluorouracil on days 1-4, repeated every 3 weeks. One patient achieved a complete response (1.8%) and 7 a partial response (12.3%), an overall response rate of 14.1% and a disease control rate of 43.9%. Median time to progression (TTP) was 2.4 months, and median overall survival (OS) 9.8 months. The main grade 3 and 4 toxicities were leucopenia (10.5%), neutropenia (21.0%) and thrombocytopenia (8.8%). Of the 45 patients with an initially elevated AFP level, 15 (33.3%) showed a reduction of more than 50%. The disease control rate was significantly higher in AFP responders (80.0 vs. 23.3% in AFP non-responders, p<0.001), who moreover exhibited prolonged TTP (p=0.010). Combination chemotherapy of 5-fluorouracil and cisplatin showed modest disease control activity and acceptable toxicity in patients with inoperable HCC. Furthermore, AFP response may be a useful surrogate marker for clinical outcome. | - |
dc.language | 영어 | - |
dc.publisher | Spandidos Publications | - |
dc.title | A Phase II study of 5-fluorouracil and cisplatin systemic chemotherapy for inoperable hepatocellular carcinoma with α fetoprotein as a predictive and prognostic marker | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.3892/mmr.1.3.415 | - |
dc.citation.journaltitle | Molecular Medicine Reports | - |
dc.identifier.wosid | 000261058000019 | - |
dc.identifier.scopusid | 2-s2.0-69249105577 | - |
dc.citation.endpage | 422 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 415 | - |
dc.citation.volume | 1 | - |
dc.identifier.sci | 000261058000019 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFUSION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | alpha fetoprotein | - |
dc.subject.keywordAuthor | 5-fluorouracil | - |
dc.subject.keywordAuthor | cisplatin | - |
dc.subject.keywordAuthor | chemotherapy | - |
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