Publications
Detailed Information
Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: Methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dae-Young | - |
dc.contributor.author | Lee, Keun-Wook | - |
dc.contributor.author | Yun, Tak | - |
dc.contributor.author | Park, Sook Ryun | - |
dc.contributor.author | Jung, Joo Young | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Kim, Noe Kyeong | - |
dc.date.accessioned | 2020-04-27T11:47:30Z | - |
dc.date.available | 2020-04-27T11:47:30Z | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2003-12 | - |
dc.identifier.citation | Japanese Journal of Clinical Oncology, Vol.33 No.12, pp.608-612 | - |
dc.identifier.issn | 0368-2811 | - |
dc.identifier.other | 95331 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165580 | - |
dc.description.abstract | Objective: To compare the efficacy of intrathecal methotrexate single therapy with three-drug combination therapy in patients with leptomeningeal carcinomatosis. Methods: Fifty-five patients who had pathologically proven leptomeningeal carcinomatosis of a solid tumor were evaluated in terms of pathological response. Group M (n = 29) received methotrexate 15 mg and group MHA (n = 26) received methotrexate 15 mg, hydrocortisone 15 mg/m(2) and ara-C 30 mg/m(2) twice a week intrathecally until a cytological response was obtained. Results: Primary sites of the tumor were the lung (n = 33), breast (n = 13) and stomach (n 5). The pathology of 45 patients was adenocarcinoma. The cytological response rate to intrathecal chemotherapy was significantly higher in the MHA group than in the M group (38.5 vs 13.8%, P= 0.036). The median survival was 18.6 weeks in the MHA arm and 10.4 weeks in the M arm (P = 0.029). Conclusion: Combination intrathecal chemotherapy with methotrexate, cytosine arabinoside and hydrocortisone showed more favorable effects than methotrexate single therapy for leptomeningeal carcinomatosis in solid tumors. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: Methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1093/jjco/hyg118 | - |
dc.citation.journaltitle | Japanese Journal of Clinical Oncology | - |
dc.identifier.wosid | 000189381800002 | - |
dc.identifier.scopusid | 2-s2.0-18544397596 | - |
dc.citation.endpage | 612 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 608 | - |
dc.citation.volume | 33 | - |
dc.identifier.sci | 000189381800002 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Keun-Wook | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Kim, Noe Kyeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MENINGEAL CARCINOMATOSIS | - |
dc.subject.keywordPlus | LEUKEMIA | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | meningeal neoplasms | - |
dc.subject.keywordAuthor | spinal injections | - |
dc.subject.keywordAuthor | methotrexate | - |
dc.subject.keywordAuthor | cytarabine | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.