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Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: Methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone

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dc.contributor.authorKim, Dae-Young-
dc.contributor.authorLee, Keun-Wook-
dc.contributor.authorYun, Tak-
dc.contributor.authorPark, Sook Ryun-
dc.contributor.authorJung, Joo Young-
dc.contributor.authorKim, Dong-Wan-
dc.contributor.authorKim, Tae-You-
dc.contributor.authorHeo, Dae Seog-
dc.contributor.authorBang, Yung-Jue-
dc.contributor.authorKim, Noe Kyeong-
dc.date.accessioned2020-04-27T11:47:30Z-
dc.date.available2020-04-27T11:47:30Z-
dc.date.created2020-04-08-
dc.date.issued2003-12-
dc.identifier.citationJapanese Journal of Clinical Oncology, Vol.33 No.12, pp.608-612-
dc.identifier.issn0368-2811-
dc.identifier.other95331-
dc.identifier.urihttps://hdl.handle.net/10371/165580-
dc.description.abstractObjective: To compare the efficacy of intrathecal methotrexate single therapy with three-drug combination therapy in patients with leptomeningeal carcinomatosis. Methods: Fifty-five patients who had pathologically proven leptomeningeal carcinomatosis of a solid tumor were evaluated in terms of pathological response. Group M (n = 29) received methotrexate 15 mg and group MHA (n = 26) received methotrexate 15 mg, hydrocortisone 15 mg/m(2) and ara-C 30 mg/m(2) twice a week intrathecally until a cytological response was obtained. Results: Primary sites of the tumor were the lung (n = 33), breast (n = 13) and stomach (n 5). The pathology of 45 patients was adenocarcinoma. The cytological response rate to intrathecal chemotherapy was significantly higher in the MHA group than in the M group (38.5 vs 13.8%, P= 0.036). The median survival was 18.6 weeks in the MHA arm and 10.4 weeks in the M arm (P = 0.029). Conclusion: Combination intrathecal chemotherapy with methotrexate, cytosine arabinoside and hydrocortisone showed more favorable effects than methotrexate single therapy for leptomeningeal carcinomatosis in solid tumors.-
dc.language영어-
dc.publisherOxford University Press-
dc.titleComparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: Methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone-
dc.typeArticle-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.1093/jjco/hyg118-
dc.citation.journaltitleJapanese Journal of Clinical Oncology-
dc.identifier.wosid000189381800002-
dc.identifier.scopusid2-s2.0-18544397596-
dc.citation.endpage612-
dc.citation.number12-
dc.citation.startpage608-
dc.citation.volume33-
dc.identifier.sci000189381800002-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorLee, Keun-Wook-
dc.contributor.affiliatedAuthorKim, Dong-Wan-
dc.contributor.affiliatedAuthorKim, Tae-You-
dc.contributor.affiliatedAuthorHeo, Dae Seog-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
dc.contributor.affiliatedAuthorKim, Noe Kyeong-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusMENINGEAL CARCINOMATOSIS-
dc.subject.keywordPlusLEUKEMIA-
dc.subject.keywordPlusTRIAL-
dc.subject.keywordAuthormeningeal neoplasms-
dc.subject.keywordAuthorspinal injections-
dc.subject.keywordAuthormethotrexate-
dc.subject.keywordAuthorcytarabine-
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