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Genomic characterization of Nocardia seriolae strains isolated from diseased fish

Cited 10 time in Web of Science Cited 8 time in Scopus
Authors
Han, Hyun-Ja; Kwak, Min-Jung; Ha, Sung-Min; Yang, Seung-Jo; Kim, Lin Do; Cho, Kyoung-Hee; Kim, Tae-Wook; Cho, Mi Young; Kim, Byung-Yong; Jung, Sung-Hee; Chun, Jongsik
Issue Date
2019-03
Citation
MicrobiologyOpen, Vol.8 No.3, p. 656
Keywords
Anguilla japonicaChanna arguscomparative genomicsfish pathogenNorcardia seriolae
Abstract
Members of the genus Nocardia are widespread in diverse environments; a wide range of Nocardia species are known to cause nocardiosis in several animals, including cat, dog, fish, and humans. Of the pathogenic Nocardia species, N. seriolae is known to cause disease in cultured fish, resulting in major economic loss. We isolated two N. seriolae strains, CK‐14008 and EM15050, from diseased fish and sequenced their genomes using the PacBio sequencing platform. To identify their genomic features, we compared their genomes with those of other Nocardia species. Phylogenetic analysis showed that N. seriolae shares a common ancestor with a putative human pathogenic Nocardia species. Moreover, N. seriolae strains were phylogenetically divided into four clusters according to host fish families. Through genome comparison, we observed that the putative pathogenic Nocardia strains had additional genes for iron acquisition. Dozens of antibiotic resistance genes were detected in the genomes of N. seriolae strains; most of the antibiotics were involved in the inhibition of the biosynthesis of proteins or cell walls. Our results demonstrated the virulence features and antibiotic resistance of fish pathogenic N. seriolae strains at the genomic level. These results may be useful to develop strategies for the prevention of fish nocardiosis.
ISSN
2045-8827
URI
https://hdl.handle.net/10371/165719
DOI
https://doi.org/10.1002/mbo3.656
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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