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Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jonghoon | - |
dc.contributor.author | Kim, Han Young | - |
dc.contributor.author | Song, Seuk Young | - |
dc.contributor.author | Go, Seok-hyeong | - |
dc.contributor.author | Sohn, Hee Su | - |
dc.contributor.author | Baik, Seungmin | - |
dc.contributor.author | Soh, Min | - |
dc.contributor.author | Kim, Kang | - |
dc.contributor.author | Kim, Dokyoon | - |
dc.contributor.author | Kim, Hyo-Cheol | - |
dc.contributor.author | Lee, Nohyun | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.date.accessioned | 2020-04-27T13:19:07Z | - |
dc.date.available | 2020-04-27T13:19:07Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | ACS Nano, Vol.13 No.3, pp.3206-3217 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.other | 90017 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165767 | - |
dc.description.abstract | Poor O-2 supply to the infiltrated immune cells in the joint synovium of rheumatoid arthritis (RA) up-regulates hypoxia-inducible factor (HIF-1 alpha) expression and induces reactive oxygen species (ROS) generation, both of which exacerbate synovial inflammation. Synovial inflammation in RA can be resolved by eliminating pro-inflammatory M1 macrophages and inducing anti-inflammatory M2 macrophages. Because hypoxia and ROS in the RA synovium play a crucial role in the induction of Ml macrophages and reduction of M2 macrophages, herein, we develop manganese ferrite and ceria nanoparticle-anchored mesoporous silica nanoparticles (MFC-MSNs) that can synergistically scavenge ROS and produce O-2 for reducing M1 macrophage levels and inducing M2 macrophages for RA treatment. MFC-MSNs exhibit a synergistic effect on O-2 generation and ROS scavenging that is attributed to the complementary reaction of ceria nanoparticles (NPs) that can scavenge intermediate hydroxyl radicals generated by manganese ferrite NPs in the process of O-2 generation during the Fenton reaction, leading to the efficient polarization of M1 to M2 macrophages both in vitro and in vivo. Intra-articular administration of MFC-MSNs to rat RA models alleviated hypoxia, inflammation, and pathological features in the joint. Furthermore, MSNs were used as a drug-delivery vehicle, releasing the anti-rheumatic drug methotrexate in a sustained manner to augment the therapeutic effect of MFC-MSNs. This study highlights the therapeutic potential of MFC-MSNs that simultaneously generate O-2 and scavenge ROS, subsequently driving inflammatory macrophages to the anti-inflammatory subtype for RA treatment. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김병수 | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1021/acsnano.8b08785 | - |
dc.citation.journaltitle | ACS Nano | - |
dc.identifier.wosid | 000462950500048 | - |
dc.identifier.scopusid | 2-s2.0-85062830247 | - |
dc.citation.endpage | 3217 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 3206 | - |
dc.citation.volume | 13 | - |
dc.identifier.sci | 000462950500048 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MESOPOROUS SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | TUMOR-ASSOCIATED MACROPHAGES | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | CERIA NANOPARTICLES | - |
dc.subject.keywordPlus | OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | IN-SITU | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | HIF-1-ALPHA | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | manganese ferrite nanoparticles | - |
dc.subject.keywordAuthor | oxygen generation | - |
dc.subject.keywordAuthor | macrophage polarization | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | nanomedicine | - |
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